Hi Jorge,

> 
> Should I look at anything else to establish twin P1 is the best way to refine 
> this structure?

You could feed your refined model and map coefficients to Zanuda (CCP4 program) 
which automatically will check which higher symmetry space group will give 
lower Rfactors in refinement, pointing to real crys symmetry (similarly to what 
you have been doing manually). 

Good luck!

D
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