ModeX Therapeutics is seeking a highlyskilled and motivated scientist to support biologics production, characterization,and optimization for developing innovative biotherapeutics. This is an excitingopportunity to be part of a cross-functional team and contribute to thedevelopment of next-generation biological therapeutics in a fast-paced, rapidlygrowing biotech company with a bold vision.
Company ModeX Therapeutics, a subsidiary of OPKOHealth, is a biotech based in Massachusetts dedicated to the concept ofmodulating multiple disease targets with innovative multi-targeting strategies.It was founded by Dr. Elias Zerhouni and Dr. Gary J. Nabel in 2020 with a teamof scientists with proven track record from early research to clinicaldevelopment, regulatory approvals, and commercialization. ModeX is pursuing thedevelopment of novel immune-oncology therapeutics for cancers and biotherapeuticsagainst infectious disease. Major responsibilities · Interact closely and be part ofinterdisciplinary biologics research teams to drive the discovery of innovative therapeutic antibodies and theoptimization of their biochemical and biophysical properties. · Contribute to ModeX’s multi-targetingstrategy through structure-based antibody design, production, andcharacterization platforms. · Develop a high-throughputantibody expression and purification platform and lead the effort in producing high-qualitymultispecific antibodies for developability assessment and PK/PD studies. · Perform biochemical andbiophysical characterization of diverse biologics molecules, includingmulti-specifics, fusion proteins, and non-viral particle to support leadcandidate selection, focusing on antibody’sbiophysical properties including chemical stability, solubility,polyspecificity and polyreactivity. · Interpret results and present/communicatewith cross-functional colleagues for successful execution and completion ofprojects. · Stayscientifically current and contribute to the implementation of new technologyand instrumentation. · Ensure effective andtimely documentation in electronic laboratory notebooks. Qualifications · PhD or MS in biochemistry,structure biology, biomedical engineering, or other life science disciplines · Minimum of 3 years (PhD)/6 years (MS) of relevant experiences · Knowledge in antibodystructure and the development of antibody-based biotherapeutics is preferred. · Skilled in protein expressionin mammalian cells and protein purification using various chromatographymethods and instruments such as AKTA FPLC. · Experience with proteinanalytic techniques such asHPLC/UPLC, cIEF/CE-SDS, SLS/DLS, and BLI/SPR based protein-protein interactioncharacterization is a plus. · Excellent written andoral communication, organization, and data analysis skills. Outstanding troubleshooting and problem-solvingskills. · Highly adaptable to afast-paced work environment and capable to work both independently andcollaboratively within project teams. To apply, please send cover letter and CVto hao.c...@modextx.com and care...@modextx.com ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
