Dear Neno,

when I asked the same question a few months ago, I ended up writing my
own program. We used it for our study of coking in the zeolite ZSM5
(https://doi.org/10.1002/anie.202205413). It is not at all user
friendly, and it reads in FCF files, rather than MTZ files. I can
send you the source code nevertheless in case you are interested, or a
linux binary. It is easy to create an FCF file from your MTZ file with
e.g. pdb2ins and a quick run of SHELXL with 'CGLS 0'.

Best,
Tim


On Wed, 10 Aug 2022 09:59:55 -0400 Neno Vuksanovic
<[email protected]> wrote:

>  Dear All,
> 
> I would like to quantify electron density inside of positive Fo-Fc
> blobs in active sites of multiple protomers in the map and compare
> them. I am aware that I can interpolate maps and obtain density
> values at coordinate points using either MapMan, Chimera or Coot, but
> I would like to know if there is a tool that would let me designate a
> sphere of a certain volume and calculate total electron density
> inside it?
> 
> Best Regards,
> Neno
> 
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--
Tim Gruene
Head of the Centre for X-ray Structure Analysis
Faculty of Chemistry
University of Vienna

Phone: +43-1-4277-70202

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