We are looking for PhD students funded or willing to apply for internal funding. Situated near the beautiful Gold Coast beaches in sunny Queensland, Australia. Our lab is located at the Institute for Glycomics at Griffith University. We have several PhD projects available.
We will use a multidisciplinary approach to develop Nanobodies against norovirus and lagovirus, including bioinformatics, X-ray crystallography, molecular biology techniques, cell culture. Projects: (a) Precisely identify essential co-factor binding sites and epitope map norovirus capsids using Nanobodies targeting clinically relevant and emerging noroviruses. (b) Produce broadly reactive norovirus Nanobodies and develop novel Nanobody-based RATs. (c) Generate norovirus Nanobody-based therapeutics targeting co-factor sites and other vulnerable regions on the capsid. 1. Koromyslova AD, Devant JM, Kilic T, Sabin CD, Malak V, Hansman GS. 2020. Nanobody-Mediated Neutralization Reveals an Achilles Heel for Norovirus. J Virol 94.10.1128/jvi.00660-20 2. Ruoff K, Kilic T, Devant J, Koromyslova A, Ringel A, Hempelmann A, Geiss C, Graf J, Haas M, Roggenbach I, Hansman G. 2019. Structural Basis of Nanobodies Targeting the Prototype Norovirus. J Virol doi:10.1128/JVI.02005-18.10.1128/JVI.02005-18 3. Koromyslova AD, Hansman GS. 2017. Nanobodies targeting norovirus capsid reveal functional epitopes and potential mechanisms of neutralization. PLoS Pathog 13:e1006636.10.1371/journal.ppat.1006636 4. Koromyslova AD, Hansman GS. 2015. Nanobody binding to a conserved epitope promotes norovirus particle disassembly. J Virol 89:2718-2730.10.1128/JVI.03176-14 Requirements: • Experience in protein structural biology • Experience in protein expression and purification • Excellent knowledge in protein structural biology • Participation in all stages of the structure determination • Demonstrated independent thought/creativity in science. Interested applicants should send CV and statement of interest to Grant Hansman: [email protected] https://experts.griffith.edu.au/26877 ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
