Dear all, There is a PhD studentship opportunity at the Institute of Cancer research, London in partnership with Diamond. This would be to start in October 2023
This project is to explore the binding of inhibitors and fragments to the cancer drug target proteins BCL6 and HSP70 using multicrystal data measured at the room temperature in situ beamline VMXi at Diamond. You will compare this room temperature data with corresponding cryogenic data of the same complexes. You will also have the opportunity to investigate the influence of X-ray radiation damage to bound ligands containing heavier atoms such as halogens and the influence this has on binding modes. The knowledge gained will be broadly applicable to drug design methods as well as providing specific advances in drug discovery for these two important cancer targets. The project offers the chance to work at one of the world's leading drug discovery centres at the ICR and in close partnership with the U.K.'s national synchrotron facility at Diamond. Full details are available here: https://www.icr.ac.uk/studying-and-training/phds-for-science-graduates/phd-studentship-projects under the project title Exploring the differences in the structural characterisation of inhibitor binding between cryo- and room-temperature using multicrystal X-ray crystallography the application deadline is 13th of November 2022. for informal queries please contact Dr Rob van Montford : [email protected]<mailto:[email protected]> or myself at: [email protected]<mailto:[email protected]> Thanks, Mike -- This e-mail and any attachments may contain confidential, copyright and or privileged material, and are for the use of the intended addressee only. If you are not the intended addressee or an authorised recipient of the addressee please notify us of receipt by returning the e-mail and do not use, copy, retain, distribute or disclose the information in or attached to the e-mail. Any opinions expressed within this e-mail are those of the individual and not necessarily of Diamond Light Source Ltd. Diamond Light Source Ltd. cannot guarantee that this e-mail or any attachments are free from viruses and we cannot accept liability for any damage which you may sustain as a result of software viruses which may be transmitted in or with the message. Diamond Light Source Limited (company no. 4375679). Registered in England and Wales with its registered office at Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
