The Deaconescu Lab at Brown University has openings for two postdoctoral researchers and one technician funded by a new multi-year grant from the NIH. The laboratory's interests lie primarily in stress responses, with particular emphasis on responses to DNA damage and the mechanochemistry of large macromolecular machines. We deploy a combination of biochemical, biophysical and structural techniques. (e.g. X-ray crystallography, electron microscopy). Examples of recent work are: Schwartz et al, *Protein Science *(2021), Brugger et al, *Nature Communications *(2020), Dorich et al, *Genes & Development *(2019), Vemu et al. *Science *(2018), Le TT et al. *Cell* (2018), Szyk et al and *Cell* (2014).
*Successful postdoctoral candidates* should have an established track-record of publications in peer-reviewed journals. One position will be focused on protein purification and characterization, assay development, inhibitor screening and X-ray crystallography. The other will focus on specimen preparation for cryo-EM, data collection and processing. We have a variety of projects available at different stages of development and are well equipped with our own crystallization robot (Mosquito) and grid plunger (Vitrobot Mark IV). Prior knowledge of crystallography and/or single-particle electron microscopy is highly desirable, but not required. Must be highly motivated and work well independently as well as in a team. Excellent spoken and written English are required. New Ph.D. graduates are encouraged to apply. *A successful technician candidate* should preferably have a degree in chemistry/biological sciences and more than two years experience at the bench, at the minimum with molecular biology, and ideally, also with protein purification and crystallization. *Interested candidates should send a CV, a one page research experience summary and contact information for three references to * alexandra_deaconescu[at]brown.edu. Please use “postdoctoral candidate” or “research technician” as a subject. Salary and starting date are negotiable. Brown University, an Ivy League school ranked as 5th best in the US by the Wall Street Journal, is located in Providence, Rhode Island less than one hour away by train from Boston. Rhode Island provides plenty of opportunities for outdoor recreation with beautiful beaches and sailing. Lab webpage: https://deaconesculab.com ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
