You are cordially invited to join the Center for Biomolecular Structure Lecture Series ………..
Andres Finzi Canada Research Chair on Retroviral Entry Member of The College of the Royal Society of Canada Associate Professor, Faculty of Medicine, Université de Montréal WEDNESDAY, December 14, 13:30 (EST) "Modulating HIV-1 Env conformation to eliminate infected cells" Register in advance for this meeting: https://bnl.zoomgov.com/meeting/register/vJItcO6hrTMpGQ0PHGXLvZgC2gWbXrF4-3I Time conversion Link: https://www.worldtimebuddy.com/<https://urldefense.com/v3/__https:/gcc02.safelinks.protection.outlook.com/?url=https*3A*2F*2Fwww.worldtimebuddy.com*2F&data=05*7C01*7Cgenoa.blankenship*40pnnl.gov*7C67ffe754733240e42d3e08da641ba4bc*7Cd6faa5f90ae240338c0130048a38deeb*7C0*7C0*7C637932367171794987*7CUnknown*7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0*3D*7C3000*7C*7C*7C&sdata=aSe2IUSomjge9ZW6zXdQ81fPzxpg8eawtRkoiOEJdXM*3D&reserved=0__;JSUlJSUlJSUlJSUlJSUlJSUlJSU!!P4SdNyxKAPE!Fd5kIAbibocFpkUaEbpqZZGm8tw-xiqb5oC4sfOklv6Kbbf-T3RvUobMSLrzyXNbfNVT9vMxJGuY1RsSqbc6MjpIABre1Q$> Abstract: HIV-1 evolved to conceal its envelope glycoproteins (Env) from recognition by antibodies elicited in most infected individuals. This lack of recognition translates into a lack of neutralization. Therefore, these antibodies are known as non-neutralizing antibodies (nnAbs). However, antibodies have several functions beyond neutralization, with Fc-effector functions being scrutinized in the last few years. Unfortunately, nnAbs also fail to eliminate infected cells due to their incapacity to recognize Env. We developed a new strategy to “open up” Env at the surface of infected cells thus enabling recognition by nnAbs. This approach renders infected cells susceptible to antibody-dependent cellular cytotoxicity (ADCC) and therefore it could represent a new tool to achieve a functional cure. Bio: Dr. Finzi is Associate Professor and Canada Research Chair on Retroviral Entry at Université de Montréal. Dr Finzi is a leader in HIV-1 envelope glycoprotein conformational changes, accessory proteins and Fc-mediated effector functions. His work has important implications for the development of new therapeutic strategies to fight HIV-1. The excellence of Dr Finzi’s research program has been recognized by several distinctions and awards. Since November 2020 he is a Member of The College of the Royal Society of Canada. ================== Vivian Stojanoff, PhD Education, Training, Outreach User Program p 1(631) 344 8375 e lifesciences@<mailto:nsls.lifescien...@gmail.com>bnl.gov w https://www.bnl.gov/ps/lifesciences/<https://www.bnl.gov/ps/lsbr/> Address: Center for Biomolecular Structure National Synchrotron Light Source II Building 745 Brookhaven National Laboratory Upton NY 11973 ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
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FINZI GA - 11-22-22.pdf
Description: FINZI GA - 11-22-22.pdf
