Dear all, There is a PhD studentship available in my lab at the Leicester Institute of Structural and Chemical Biology, University of Leicester, in partnership with the biopharmaceutical company, UCB. This position would be to start in October 2023
We will use an innovative antibody-assisted drug discovery approach to target key drivers of chronic inflammatory conditions. This will involve the generation of high affinity antibodies and nanobodies against fully validated inflammatory drug targets to allow for the identification, characterisation, and exploitation of new opportunities for drug discovery. This project would be an opportunity to further capitalise on the expertise developed within the research group and allow us to investigate the use of knob domains, found in bovine antibodies, as an alternative to single chain antibodies, to understand how these smaller modalities access different epitopes and improve the probability of obtaining structural data to facilitate the identification of functional, small molecule hits. Protein crystal structures will be obtained for a selected portfolio of nanobodies bound to target proteins, which will provide an essential foundation for both structure-based design and fragment-based screening approaches to obtain small molecule modulators of activity, providing a novel, potentially more effective route to develop small molecule therapeutics. The project will also provide thorough research training in many aspects of protein science, structural biology and functional assays, together with the opportunity for the PhD student to spend an extended period (3-6 months) working at the UCB site in Slough. Full details are available at: https://le.ac.uk/study/research-degrees/funded-opportunities/future-50-ri. The application deadline is 20th of January 2023. Please contact Dr Gareth Hall: gh...@leicester.ac.uk<mailto:gh...@leicester.ac.uk> or Dr Cyril Dominguez: cd...@leicester.ac.uk<mailto:cd...@leicester.ac.uk> for further informal details. Thanks, Gareth ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
