This is always hard to see this way, but it looks like glycerol at first 
glance. Try to fit that.

Cheers,
Robbie

> -----Original Message-----
> From: CCP4 bulletin board <[email protected]> On Behalf Of zeyaul
> islam
> Sent: Tuesday, February 21, 2023 12:13
> To: [email protected]
> Subject: [ccp4bb] Unidentified density
> 
> Dear all
> 
>  We have solved the structure of nanobody at 1.25 angstrom. We observe some
> unidentified density near the serine. Please have a look at the figures. 
> Protein
> was purified in PBS buffer (137 mM NaCl, 2.7 mM KCl, 8 mM Na2HPO4, and 2
> mM KH2PO4) and the crystallisation condition has 0.1 M BIS-TRIS pH 5.5, 2.0 M
> ammonium sulfate. Any ideas what this could be? I tried SO4 and PO4 but
> didn’t satisfy the observed electron density.
> 
> I appreciate any help you can provide.
> 
> Thanks
> 
> Zeya
> 
> Zeyaul Islam, PhD
> 
> QBRI - Qatar Biomedical Research Institute
> 
> P.O. Box: 34110
> Doha – Qatar
> 
> Tel: +974 445 46690
> 
> 
> 
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