Dear colleagues, I would like to advertise an EPSRC-funded studentship that is available in my lab at the University of Edinburgh:
"The physics and structural biology of supramolecular protein self-assembly in meiotic chromosome synapsis" One of the largest protein structures in the cell is the synaptonemal complex (SC), which synapses together homologous chromosomes to facilitate their recombination during meiosis. This project aims to uncover the physics of how the SC is formed through self-assembly of its protein components. This will involve a wide range of biochemical, biophysical, structural biology, computational and theoretical modelling methods. The laboratory-based methods include recombinant protein expression and purification, light and X-ray scattering, X-ray crystallography, cryo-EM and cryo-ET, which will include data collection at the Diamond Light Source synchrotron facility (www.diamond.ac.uk<https://www.findaphd.com/common/clickCount.aspx?theid=156057&type=184&DID=3300&url=http%3a%2f%2fwww.diamond.ac.uk%2f>). Computational and theoretical methods include AI-based structural modelling, molecular dynamics, and building and simulating mathematical models of bio-assemblies, which will be performed in collaboration with the Institute for Condensed Matter and Complex Systems (https://www.ph.ed.ac.uk/icmcs<https://www.findaphd.com/common/clickCount.aspx?theid=156057&type=184&DID=3300&url=https%3a%2f%2fwww.ph.ed.ac.uk%2ficmcs>). This PhD provides an excellent opportunity for a student with a biochemical/structural biology, computational or physics background to engage in cutting-edge research into the physics of life. For more information, please see: https://www.findaphd.com/phds/project/the-physics-and-structural-biology-of-supramolecular-protein-self-assembly-in-meiotic-chromosome-synapsis/?p156057 To apply, please follow the 'institution website' link at the above address and complete the application form. Application deadline: 31st March Best wishes, Owen. Dr Owen Davies Wellcome Senior Research Fellow Institute of Cell Biology University of Edinburgh Michael Swann Building Max Born Crescent Edinburgh EH9 3BF United Kingdom The University of Edinburgh is a charitable body, registered in Scotland, with registration number SC005336. Is e buidheann carthannais a th' ann an Oilthigh Dh?n ?ideann, cl?raichte an Alba, ?ireamh cl?raidh SC005336. ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
