Dear all,

We have an exciting collaborative PhD studentship project between Keele 
University (Dr Annette Shrive) and Diamond Light Source (Dr Halina Mikolajek 
and Dr David Owen), the UK’s national synchrotron science facility located at 
the Harwell Science and Innovation Campus. The project will use a variety of 
techniques in structural biology, including X-ray crystallography and 
cryo-electron microscopy (cryoEM), at both Keele and Harwell to characterise 
structurally the interactions and effector mechanisms of the innate immune 
proteins, human C-reactive protein (CRP) and complement component C1q. The 
innate immune molecule CRP and the complement system play key roles in 
infection and inflammation. There is much biological and medical interest in 
their role including how they relate to inflammatory processes including 
cardiovascular and autoimmune diseases.

The student will spend half of their time at Keele University and time at 
Diamond Light Source.

To read further details and apply, see the advert here:
https://www.diamond.ac.uk/Careers/Students/Studentships/2023-projects/2023-STU0473.html
 under the title Structural insight into human C-reactive protein effector 
mechanisms [STU0473]

The application deadline is 14th April 2023 for a starting date in October 2023.

If you have any questions about the project, don't hesitate to contact either 
myself: [email protected] or Dr Annette Shrive at: 
[email protected].

Kind regards
Halina

Dr Halina Mikolajek
Research Scientist at VMXi and Crystallisation Facility Manager
Diamond Light Source
Harwell Science and Innovation Campus
Didcot
OX11 0DE
UK

[email protected]


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