I was afraid of this happening at some point and decided to start a new career 
~ten years ago and use structures only as a tool and never put them into the 
centerpiece of a grant.

My fall back option is either a cocktail bar or starting a restaurant. The 
Triple M’s always work Mojito, Martini, Manhattan 

Jürgen 
> On Apr 1, 2023, at 11:29 AM, Dale Tronrud <[email protected]> wrote:
> 
> Hi,
> 
>   Just ask ChatGPT to write it for you!
> 
> Dale Tronrud
> 
> 
> 
> On 4/1/2023 5:06 AM, Subramanian, Ramaswamy wrote:
>> Dear All,
>> I am unsure if all other groups will get it - but I am sure this group will 
>> understand the frustration.
>> My NIH grant did not get funded.  A few genuine comments - they make 
>> excellent sense.  We will fix that.
>> One major comment is, “Structures can be predicted by alpfafold and other 
>> software accurately, so the effort put on the grant to get structures by 
>> X-ray crystallography/cryo-EM is not justified.”
>> The problem is when a company with billions of $$s develops a method and 
>> blasts it everywhere - the message is so pervasive…
>> *Question: I*s there a canned consensus paragraph that one can add with 
>> references to grants with structural biology (especially if the review group 
>> is not a structural biology group) to say why the most modern structure 
>> prediction programs are not a substitute for structural work?
>> Thanks.
>> Rams
>> [email protected]
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