Sorry - the simplest answer - is get higher resolution data!
But there are some improvements possible.
How clear is your MR solution.
What is the similarity between model and your sequence?
Etc.


On Tue, 21 Nov 2023 at 12:03, Yahui Liu <[email protected]> wrote:

> Dear all,
> I got a protein crystal dataset of 4.3 A and would like to some the
> structure with MR.
> Now I am suffering with the refinement. I used both Refmac and Phenix.
>
> Someone could give me a hand or  any suggestions?
>
> All the best
>
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