Dear CCP4 Community, I am delighted to share an exciting postdoctoral opportunity within my lab at Stanford University (visit us at https://rogala.stanford.edu). We have recently secured funding for this post, and we are actively seeking individuals with a passion for membrane protein structural biology, biochemistry, and biophysics. Our lab is relatively young, and we are in search of driven candidates with a start-up mentality and a passion for exploring the fundamental mechanisms of protein function. While technical expertise in membrane proteins is desirable, it is not a requirement, and we welcome applications from candidates with a strong interest in our field. Compensation of our postdocs is set to the Stanford rates <https://postdocs.stanford.edu/funding-rates-and-guidelines>.
At the heart of our scientific exploration are the questions of (i) how cells control their metabolism in response to nutrients, and (ii) how starving cancer cells cheat death by scavenging nutrients from their environment. We are a team of structural and chemical biologists committed to understanding the basic principles of cell signaling on the biological membrane, with a special emphasis on nutrient transporters and large peripheral membrane complexes involved in nutrient sensing. Key Qualifications: ‣ Deep curiosity and a strong drive to lead a project of your own. ‣ Start-up mentality and a passion for fundamental membrane protein research. ‣ Hands-on membrane protein experience is desirable but not required. To apply, visit the official postdoc advertisement on the Stanford website [ here <https://postdocs.stanford.edu/prospective/opportunities/open-postdoctoral-position-faculty-mentor-kacper-rogala>]. Please share a few lines about yourself, your previous research experience, and what excites you about our lab. Include your CV and contact details for three references. We look forward to welcoming a driven and enthusiastic postdoc to our team! Please share this opportunity with potential candidates. We offer a flexible start date for those anticipating the completion of their PhDs within the next 12 months. Many thanks and best wishes, Kacper KACPER ROGALA, D.PHIL. *Assistant Professor* *–––––––––––––––––––––––––––––––-* Department of Structural Biology <https://med.stanford.edu/structuralbio.html> Department of Chemical and Systems Biology <https://chemsysbio.stanford.edu/> Stanford Cancer Institute <http://med.stanford.edu/cancer.html> Stanford University School of Medicine Biomedical Innovations Building 240 Pasteur Drive, 4700 | Palo Alto, CA, 94304 https://rogala.stanford.edu Extra information about our lab: We are a team of structural and chemical biologists fascinated by how cells control their metabolism in response to nutrients. How are nutrients recognized by their protein sensors? How is their transport across cellular and intracellular membranes regulated? And, how is nutrient sensing integrated with other chemical signals, such as growth factors, to determine cellular decisions, especially the decision: to grow or not to grow? We are aiming to answer these fundamental questions at the level of ångstroms, nanometers, and micrometers — with cryo-EM, X-ray crystallography, and a full range of other techniques. Many proteins in nutrient signaling pathways are deregulated in cancer, and in parallel to the mechanistic structural work, we are also developing targeted chemical probes to modulate activity of these proteins in cells and organisms. We primarily work on proteins that associate with biological membranes — either as large peripheral membrane complexes, or as integral membrane transporters. Our latest papers on this topic are: - (REVIEW) Linde-Garelli and Rogala (2023) Structural mechanisms of the mTOR pathway. Current Opinion in Structural Biology. 82:102663. PMID: 37572585 <https://pubmed.ncbi.nlm.nih.gov/37572585/>. - Valenstein and Rogala et al. (2022) Structure of the nutrient-sensing hub GATOR2. Nature, 607(7919):610-616. PMID: 35831510 <https://pubmed.ncbi.nlm.nih.gov/35831510/>. - Rogala et al. (2019) Structural basis for the docking of mTORC1 on the lysosomal surface. Science, 366(6464):468-475. PMID: 31601708 <https://pubmed.ncbi.nlm.nih.gov/31601708>. - Shen and Rogala et al. (2019) Cryo-EM structure of the human FLCN-FNIP2-Rag-Ragulator complex. Cell, 179(6):1319-1329.e8. PMID: 31704029 <https://pubmed.ncbi.nlm.nih.gov/31704029>. ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
