Dear Marius,

could the 'refinement exclude' keyword for refmac5 help?
refinement exclude all from [residue] [chain] to [residue] [chain]

Best regards,
Martin

On Tue, 2024-03-05 at 14:06 +0100, Ilme Schlichting wrote:
> Dear Marius,
> 
> Thomas discussed this issue in great detail in the supplement of our 
> recent publication
> https://www.nature.com/articles/s41586-024-07032-9
> 
> Good luck,
> 
> Ilme
> 
> On 28/02/2024 17:43, Marius Schmidt wrote:
> > Dear All,
> > can someone quickly update me with a
> > way to refine a mixture of structures in
> > refmac or phenix.
> > For example, the mixture consists of
> > 80 % structure 1 and 20 % structure 2.
> > It is important that structure 1 is kept
> > fixed (is not refined) and only structure
> > 2 is varied.
> > 
> > Best
> > Marius
> > 
> > 
> > Marius Schmidt, Dr. rer. Nat. (habil.)
> > Professor
> > University of Wisconsin-Milwaukee
> > Kenwood Interdisciplinary Research Complex
> > Physics Department, Room 3087
> > 3135 North Maryland Avenue
> > Milwaukee, Wi 53211
> > phone (office): 1-414-229-4338
> > phone (lab): 414-229-3946
> > email: [email protected]
> > https://uwm.edu/physics/people/schmidt-marius/ 
> > <https://uwm.edu/physics/people/schmidt-marius/>
> > https://sites.uwm.edu/smarius/ <https://sites.uwm.edu/smarius/>
> > https://www.bioxfel.org/ <https://www.bioxfel.org/>
> > Nature News and Views: 
> > https://www.nature.com/articles/d41586-023-00504-4 
> > <https://www.nature.com/articles/d41586-023-00504-4>
> > 
> > 
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