Dear all, A 3-year PhD position is available within the IMMUDOCS doctoral pilot project in my lab at the Structural Bioinformatics Laboratory, Åbo Akademi University, Turku, Finland: Expanding Toolbox for Targeted Oncotherapy: Intercepting Clever-1.
Our research focuses on the structural, biochemical and biophysical analyses of proteins involved in inflammation, infection and cancer. We use a wide range of techniques including molecular biology, protein expression and purification, biochemical and biophysical protein interaction studies, X-ray crystallography, SAXS and Cryo-EM. The open PhD position is part of a larger interdisciplinary effort towards developing Clever-1-targeted immunotherapy. Novel cancer treatments complementary to the immune checkpoint targeting therapies are urgently needed to combat currently non-treatable cancers. Macrophage-targeted therapies, which break the immune-tolerance of tumors and assist activating host immune defense mechanisms, belong to these innovative treatments. Targeting Clever-1 with anti-Clever-1 antibody bexmarilimab interferes with the immunosuppressive properties of macrophages and slows the spread of cancer. As part of the project, we will determine the 3D structure for Clever-1 and elucidate its interactions with bexmarilimab at the atomic level to uncover inhibitory epitope. The obtained results will enable structure-based drug design of small molecular inhibitors expanding the toolbox for Clever-1-targeted oncotherapy. We are looking for a self-motivated PhD student with good communication skills and a strong interest in structural biology, protein biochemistry, biophysics and structure-function relationship and a previous exposure to relevant research areas during their master education. Applicants must have accomplished their Master's studies (or equivalent) on July 31 2024. The application must be made online before April 15th, 2024: https://abo.rekrytointi.com/paikat/index.php?jid=780&key=&o=A_RJ&rspvt=ba2lzeepo68kg04g0kgsw044o80kccg <https://abo.rekrytointi.com/paikat/index.php?jid=780&key=&o=A_RJ&rspvt=ba2lzeepo68kg04g0kgsw044o80kccg> Do not hesitate to contact me if you have any questions. Best wishes, Tiina ********************************************** Tiina A. Salminen, Professor Head of Subject Cluster for Biochemistry and Cell Biology Structural Bioinformatics Laboratory and InFLAMES Research Flagship Center Biochemistry, Faculty of Science and Engineering Abo Akademi University Tykistökatu 6A FI-20520 Turku Finland ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
