I think you are right, in the final equilibrium all the moisture would condense 
on the (evaporator?) coils, and there should be provision for them to drip into 
a reservoir outside. However each time the door opens and humid air is 
admitted, there will be condensation everywhere. If you leave the plate reader 
powered on, it will be slightly warmer (some parts more so than others) than 
the walls, floor, and bench, so will not be able to compete effectively for 
collecting moisture, and will be the first to dry off as the humidity goes 
down. The real chance for condensation is when you finish and take it out of 
the cold.  Laptops I enclose in a plastic bag when removing from the cold, 
don't know how practical that would be for your plate reader.
eab

Markus Seeliger wrote on 7/26/2024 11:09 AM:
Dear All,
apologies for the off-topic question. I am facing the problem of running enzyme activity 
assays at low temperature (close to 4C would be ideal) in a fluorescence plate reader. 
Before I get labeled in our department as "the one who voids warranties" and 
destroys our beloved plate reader, I wanted to pick your communal brains for any 
experience on this matter.
It is odd - we have had FPLCs, drop setting robots, PCs etc in the cold room 
for years without much problem, but I have scruples about putting a plate 
reader in frigid environments. I assume that humidity and condensation would be 
the number 1 threat to the plate reader (aside from yours truly and his merry 
coworkers), and if you have any advice on how to minimize humidity in the cold 
environment, I would appreciate any suggestions.
Am I wrong to think that most condensation should occur on the heat exchangers 
of the cold box/cold room which are the coldest spot in the system and 
therefore humidity should be reasonably low within the chilled volume (unless 
we frequently open and close the doors to the jungle-like atmosphere of the 
lab)?

Thank you for your advice

Markus

*******************************************************
Markus Seeliger

Professor
Department of Pharmacological Sciences
Stony Brook University Medical School, BST 7-170
Stony Brook, NY 11794-8651
office: (631) 444-3558
lab: (631) 638-1299
fax: (631) 444-9749

https://www.pharm.stonybrook.edu/markus-seeliger-lab-welcome

[email protected] <mailto:[email protected]>
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