Dear CCP4 Community, I am excited to share two new postdoctoral opportunities in my lab at Stanford University (visit us at https://rogala.stanford.edu).
Our research focuses on two core questions: (i) how cells control their metabolism in response to nutrients, and (ii) how nutrient‑deprived cancer cells evade death by scavenging nutrients from their environment. We are structural and chemical biologists investigating signaling at biological membranes, with a particular emphasis on nutrient transporters and large peripheral membrane complexes involved in nutrient sensing. We are seeking individuals with a start‑up mentality and a passion for uncovering fundamental mechanisms of protein function. Applicants should have a strong background in either cryo‑ET or membrane protein biochemistry. Postdoc compensation follows Stanford rates <https://postdocs.stanford.edu/funding-rates-and-guidelines> and includes a comprehensive benefits package <https://postdocbenefits.stanford.edu/general-information-and-instructions>. Key Qualifications: ‣ Expertise in either (i) cryo-ET or (ii) membrane protein biochemistry / structural biology. ‣ Deep curiosity and a strong drive to lead a project. ‣ Start‑up mentality and passion for fundamental membrane protein research. ‣ Ability and willingness to collaborate closely with other lab members. To apply, please message me directly with a brief note about yourself, your prior research experience, and what excites you about our lab. Include your CV and contact details for three references. We look forward to welcoming driven and collegial postdocs to our team! Please share this opportunity with potential candidates. We offer flexible start dates for those anticipating the completion of their PhDs within the next 12 months. Many thanks and best wishes, Kacper KACPER ROGALA, D.PHIL. *Assistant Professor* *–––––––––––––––––––––––––––––––-* Department of Structural Biology <https://med.stanford.edu/structuralbio.html> Department of Chemical and Systems Biology <https://chemsysbio.stanford.edu/> Stanford Cancer Institute <http://med.stanford.edu/cancer.html> Stanford University School of Medicine Biomedical Innovations Building 240 Pasteur Drive, 4700 | Palo Alto, CA, 94304 https://rogala.stanford.edu Extra information about our lab: We are a team of structural and chemical biologists fascinated by how cells control their metabolism in response to nutrients. How are nutrients recognized by their protein sensors? How is transport across cellular and intracellular membranes regulated? And how is nutrient sensing integrated with other signals, such as growth factors, to determine cellular decisions—especially the decision to grow or not to grow? We aim to answer these questions across scales (ångstroms, nanometers, micrometers) using cryo‑EM, X‑ray crystallography, and complementary biochemical, biophysical, and cell biology techniques. Many proteins in nutrient signaling pathways are dysregulated in cancer, and in parallel with mechanistic structural work, we develop targeted chemical probes to modulate their activity in cells and organisms. We primarily work on proteins associated with biological membranes — large peripheral membrane complexes and integral membrane transporters. Selected recent work: - Taylor, Chen, Hancock, & Wranik et al. (2025) Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2. Science, PMID: 41308123 <https://pubmed.ncbi.nlm.nih.gov/41308123/>. - Valenstein & Wranik et al. (2025) Structural basis for the dynamic regulation of mTORC1 by amino acids. Nature, PMID: 40836086 <https://pubmed.ncbi.nlm.nih.gov/40836086/>. - (REVIEW) Linde-Garelli & Rogala (2023) Structural mechanisms of the mTOR pathway. Current Opinion in Structural Biology, PMID: 37572585 <https://pubmed.ncbi.nlm.nih.gov/37572585/>. - Valenstein & Rogala et al. (2022) Structure of the nutrient-sensing hub GATOR2. Nature, PMID: 35831510 <https://pubmed.ncbi.nlm.nih.gov/35831510/>. ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
