Hi All,

I have a questions for refinement of a partially hydrolysed GMPPNP
structure. From the Fo-Fc difference density, I can tell part of the
density for the gamma phosphate represents the original gamma phosphate of
GMPPNP, and part of the density represents PO4- ion which is the product of
GMPPNP hydrolysis. I tried to model both molecules (GMPPNP, and GNH+PO4-)
and give 0.5 occupancy for both molecules. Obviously the refinement did not
work because 2 molecules are too close to each other.

The questions is: how do I set up the phenix.refine so that the 2
molecules can be refined together.


Thanks a lot!

Friday

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