Dear community,
The ESRF MXIS group and the Institute for Advanced Biosciences (IAB) in
Grenoble are jointly offering a fully-funded 3-year PhD position to
study how mutations in the mitochondrial respiratory Complex IV genes
drive Complex IV remodelling and contribute to chemoresistance in acute
myeloid leukaemia (AML).
The project integrates structural biology — SAXS and cryo-EM at the ESRF
— with biochemical, biophysical and cell-based approaches at the IAB,
including RNA-seq and mitochondrial phenotyping before and after
cytarabine treatment. The aim is to build a mechanistic model linking
Complex IV alterations to disrupted mitochondrial homeostasis and
reduced drug sensitivity.
We are looking for a candidate with a degree allowing enrolment in a PhD
(MSc, Master 2 de Recherche, Laurea or equivalent) in chemistry, biology
or a closely related field. A background in molecular biology,
structural biology and/or bioinformatics is an asset. Proficiency in
English (the working language at the ESRF) is required. The successful
candidate will be enrolled at Université Grenoble Alpes (EDCSV Doctoral
School), with an ideal start date in September 2026.
More details and how to apply:
https://esrf.gestmax.eu/1987/1/phd-student-gates/en_US
Informal enquiries are welcome to Julie Mondet ([email protected])
or Montserrat Soler-Lopez ([email protected]).
Applications will be reviewed on a rolling basis until the *deadline of
15 July 2026*. I would be grateful if you could share this with any
potentially interested candidates.
Many thanks.
montse
Head of Macromolecular Crystallography, Imaging and Scattering Group at
the ESRF.
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