Hi all,

Just wanted to see what people think about using the BioModels 
qualifiers (http://biomodels.net/index.php?s=Qualifiers) in CellML 
models? i.e., following the SBML annotation specification (see section 6 
of the SBML level 2 version 2 specification).

The reason I ask is that I am starting to look at how to reference 
external data, for example to justify a parameter value or provide 
experimental data for use in making a graph. At least for these examples 
the http://biomodels.net/model-qualifiers/isDescribedBy qualifier seems 
quite appropriate - where the referenced resource could be a journal 
publication to justify a parameter value or a reference to some 
experimental data.

Before progressing too far with this, I thought I'd better check. One 
problem I can see immediately is that the 
http://biomodels.net/model-qualifiers/is and/or 
http://biomodels.net/biology-qualifiers/is qualifiers are pretty much 
the same as the cmeta:bio_entity already defined in the CellML Metadata 
Specification. So is there already something in the CellML metadata 
specification that will let me reference arbitrary (possibly external) 
resources? Is it ok to just use the BioModels qualifiers that we want 
without supporting them all? Or is there some other way to achieve the 
same result?

I know Carey did some initial work looking at using the XML Resource 
Directory Description Language (RDDL, www.rddl.org) to reference 
external data. To make full use of this (especially in regard to model 
curation), I think we would need to define our own natures (roles) and 
purposes (arcroles) - which would essentially result in the same 
metadata as using the BioModels qualifiers but with different namespaces.


David.

-- 
David Nickerson, PhD
Research Fellow
Division of Bioengineering
Faculty of Engineering
National University of Singapore
Email: [EMAIL PROTECTED]
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