Thank you Nicolas.
I thought that this might have been the case. I believe we can mimic
your events as you describe them below in CellML by using piecewise
equations.
Just out of interest, where did you get these descriptions from? The
original paper? Correspondence with the authors? Or did you come up
with them yourselves?
We will attempt to implement these equations in the CellML models and
I will let you know if we are successful.
Best wishes
Catherine
On 29/12/2008, at 10:35 AM, Nicolas Le novère wrote:
Catherine Lloyd wrote:
Looking at the equations in the papers we can't find any function
which would cause the models to loop. Indeed, even where we have
access to the author's original XPP code, we are struggling to find
the "loop function" (although, we confess this may be due to our
misinterpretation of the XPP!).
In SBML is it possible that an event is used to get the model to
repeat? (My apologies for my ignorance here!).
Indeed, the events are responsible of the cycling. For Novak and
Tyson 1997, they are described in Table 1, in the section
"switches". There are two events:
S-Phase Start
=============
When SPF becomes superior or equal to 0.1
after 60 seconds kp = kp / 2
Cell division
=============
When UbE becomes inferior or equal to 0.1
immediately kp = 2 * kp
Mass = Mass / 2
--
Nicolas LE NOVERE, Computational Neurobiology, EMBL-EBI, Wellcome-
Trust
Genome Campus, Hinxton CB101SD UK, Mob:+447833147074, Tel:
+441223494521
Fax:468, Skype:n.lenovere, AIM:nlenovere, MSN:[email protected]
http://www.ebi.ac.uk/~lenov/, http://www.ebi.ac.uk/compneur/
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