Hi David, thanks for your kind reply. The link for OpenRave is the correct one. The SOFA link is http://www.sofa-framework.org/ . What SOFA does well is provide a suitable architecture for interactive medical simulation at the organ level. Where CellML will complement it is modeling processes at the cell and tissue levels, thereby complementing what SOFA has already in the development of multi-scale interactive medical simulation, especially if it is possible to distribute the computation, either over several cores, or over several GPUs.
I don't have a mathematical expression for this change in porosity of the BBB. You could say that I'm still dipping my toe in the pool, in terms of my immersion in computational biology. I imagine that if there is a model for diffusion of molecules accross a tissue layer, that would be a place to start, but ideally, I would like something that is well adapted to the blood-brain barrier itself. I guess Google is my friend, and I can report back if I find such an expression. Cheers, Michel The basic idea that I have is to pursue the development of Michel Audette, Ph.D. Assistant Professor, Department of Modeling, Simulation and Visualization Engineering, Old Dominion University, Norfolk, VA. ________________________________________ From: [email protected] [[email protected]] On Behalf Of David Nickerson [[email protected]] Sent: Wednesday, August 15, 2012 7:23 PM To: CellML Discussion List Subject: Re: [cellml-discussion] naive questions about modeling blood-brain barrier and its disruption Hi Michel, Thanks for the enquiry. Just because this is a completely new type of application, to me at least, could you please provide a couple of pointers to some more information. A quick google shows http://openrave.org/ - is that the simulation tool that you are referring to? But I can't find anything obvious for SOFA... And do you know of any introductory papers or other documents which might provide a bit of detail as to the mathematics you would like to encode in CellML for this particular application. Cheers, David. On Thu, Aug 16, 2012 at 7:07 AM, Audette, Michel A. <[email protected]> wrote: > Dear CellML developers and users, > > I would like to write a white paper to the US Dept of Defense that describes > how CellML might be combined with SOFA and OpenRave-based robotic therapy > simulation, where in particular I would like to leverage your toolkit to > model an increase of porosity of the blood-brain barrier, which can be > triggered by ultrasonic energy delivery, as well as the uptake of a drug. > > My knowledge of CellML is almost nil, and I'm open to any suggestion. > > Best wishes, > > Michel > > Michel Audette, Ph.D. > Assistant Professor, > Department of Modeling, Simulation and Visualization Engineering, > Old Dominion University, > Norfolk, VA. > _______________________________________________ > cellml-discussion mailing list > [email protected] > http://lists.cellml.org/mailman/listinfo/cellml-discussion _______________________________________________ cellml-discussion mailing list [email protected] http://lists.cellml.org/mailman/listinfo/cellml-discussion -- BEGIN-ANTISPAM-VOTING-LINKS ------------------------------------------------------ Teach CanIt if this mail (ID 694321490) is spam: Spam: https://www.spamtrap.odu.edu/b.php?i=694321490&m=886b274f7ff5&t=20120815&c=s Not spam: https://www.spamtrap.odu.edu/b.php?i=694321490&m=886b274f7ff5&t=20120815&c=n Forget vote: https://www.spamtrap.odu.edu/b.php?i=694321490&m=886b274f7ff5&t=20120815&c=f ------------------------------------------------------ END-ANTISPAM-VOTING-LINKS _______________________________________________ cellml-discussion mailing list [email protected] http://lists.cellml.org/mailman/listinfo/cellml-discussion
