First biological test for ADHD unveiled
http://www.newscientist.com/article.ns?id=dn6886

The first biological test for attention-deficit hyperactivity disorder has
been developed. The researchers claim the diagnosis, based on examination of
eye movements, is more than 93% accurate and could lead to earlier
identification and treatment for children with the condition.

Scientists analysed the eye movements of 65 children aged between four and
six in Thessaloniki, Greece. About half of the children had been diagnosed
as having ADHD through the standard method of psychological assessment and
the use of questionnaires.

The children were placed in front of a computer screen while wearing special
goggles to monitor their eye movements and asked to use their eyes to
"lock-on to" and follow spots of light that traversed the screen during a
10-minute test.

"Children with ADHD show large difference in eye movements compared with
normal children. For example, those without ADHD could follow the light spot
for 30 seconds to as much as five minutes, whereas the children with the
disorder could only follow the stimulus for about three to five seconds,"
says Giorgos Pavlidis at University of Brunel, UK, who led the study.

The group analysed eye movements according to various criteria, these
included fixation on the stimulus, saccades - jerking between two focal
points - and smooth pursuit. The computer was able to correctly diagnose
93.1% of the children.
Early intervention

"Children as young as three years old could benefit from the test. It could
reliably identify those children who have ADHD early on so that effective
intervention could be given to reduce loss of confidence and other
behavioural and psychological problems," Pavlidis told New Scientist.

Caroline Hensby, of the UK's ADHD support group, Adders, welcomed the
research, saying the test could be a valuable addition to current testing
procedures. "It would give sufferers a lot more confidence in their
diagnosis knowing that they had actually taken a biological test, as opposed
to just talking to someone - it would make the diagnosis more legitimate,"
she says.

"Also, it's very difficult for someone with ADHD to sit down and concentrate
for two hours - the length of current test period - so this short,
ten-minute test would be far better."
Responding to Ritalin

And Pavlidis hopes the test could be used for prognosis in the future: "Some
patients with ADHD respond well to drugs such as Ritalin, and these patients
show differences in eye movements from other ADHD sufferers both before and
after taking the drug - in fact, after taking Ritalin, the patients who
respond well to it show normal eye movements. I hope to be able to construct
a computer test that can classify those ADHD patients who will respond to
drugs."

Pavlidis estimates that between 3% and 7% of the population has ADHD, but
believes 80% of cases remain undiagnosed.

It is not known how eye neurology is affected in ADHD, but Pavlidis points
out that a symptom of the disorder is premature action - acting before
thinking - and eye movements in those with the disorder are also premature.
"The children's eyes jerk across before the light stimulus has moved," he
explains.



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