iMS SE would do you nicely.

http://www.coolfusion.com/

We use it all the time for applications such as yours.  There is an 
excellent and active support list.

Gordon


At 09:10 19/09/2002 Tormod Guldvog said....
>Hi folks -
>
>I need to create an mailing app which sends out approximately 1,000
>brief "news express" newsletters every night for my science website. I
>would like to send the e-mails in bulks of, say, 200 per 30 minutes or
>so to reduce the load on the mail servers (site is on a shared server
>and this was recommended by the ISP to avoid problems). Eventually the
>potential is more than 1,000 subscribers so I need to create a scalable
>solution.

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