If you are running on Windows then I wrote a CFX tool that will let you run
a regular expression against a query list of e-mail addresses, you can then
do MX lookups against the domain and if you are really in for the its got to
be totally clean type list, it can actually connect to the servers as
defined by the MX responses and checks the address using a couple of
techniques without actually sending an e-mail.... Funnily enough, I called
it CFX_ValidEmail :) 

http://store.newmediadevelopment.net/cfx_tag.cfm?ProductID=12

The regex tests are blisteringly fast... The MX is somewhat slower... The
SMTP connection is slower again but it guarantees that the server will
accept e-mail for the address you are checking... Whether it would bounce a
mail later (MS servers do this) is a different matter...

Paul


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