Imidacloprid is a systemic insecticide which acts as an insect neurotoxin and 
belongs to a class of chemicals called the neonicotinoids which act on the 
central nervous system of insects with much lower toxicity to mammals. The 
chemical works by interfering with the transmission of stimuli in the insect 
nervous system. Specifically, it causes a blockage in the nicotinergic neuronal 
pathway. This blockage leads to the accumulation of acetylcholine, an important 
neurotransmitter, resulting in the insect's paralysis, and eventually death. It 
is effective on contact and via stomach action.[1] Because imidacloprid binds 
much more strongly to insect neuron receptors than to mammal neuron receptors, 
this insecticide is selectively more toxic to insects than mammals.[2]
Imidacloprid is currently the most widely used insecticide in the world.[3] 
Although it is now off patent, the primary manufacturer of this chemical is 
Bayer CropScience, (part of Bayer AG). It is sold under many names for many 
uses; it can be applied by soil injection, tree injection, application to the 
skin of the plant, broadcast foliar, ground application as a granular or liquid 
formulation, or as a pesticide-coated seed treatment.[4][5] Imidacloprid is 
widely used for pest control in agriculture. Other uses include application to 
foundations to prevent termite damage, pest control for gardens and turf, 
treatment of domestic pets to control fleas,[2] and protection of trees from 
boring insects.[6]
Recent research suggests that widespread agricultural use of imidacloprid and 
other pesticides may be contributing to honey bee colony collapse disorder, the 
decline of honey bee colonies in Europe and North America observed since 
2006.[7][8][9] As a result, several countries have restricted use of 
imidacloprid and other neonicotinoids.[7] In January 2013, the European Food 
Safety Authority stated that neonicotinoids pose an unacceptably high risk to 
bees, and that the industry-sponsored science upon which regulatory agencies' 
claims of safety have relied on may be flawed, or even deceptive. [10] [11]



Contents
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1 Authorized uses
2 Application to trees
3 Background
4 Brand names
5 Biochemistry
6 Environmental fate
7 Toxicology




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