So the question is, is there a difference?  I have hundreds of GB's
to backup so if there is a performance difference one way or the
other, I would want to know.  The only thing I can see as a
difference is if I trunk the iSCSI vlan, then the traffic never hits
the 6509's routing module. Maybe that helps performance?


If I've understood you correctly, then there's no difference - the 6500 will forward 1gig layer2 just as quick as 1gig layer3.

There are some possible differences if the linecard does not have a DFC, or is a bus-linecard and the bus is contended; it would depend on what other traffic was flowing through the box.
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