Eric,
I ran in the exactly same problem as you were having.  And 'no fixup smtp
25' was the fix.

-Frank

On Wed, 21 Mar 2001, Eric McMasters wrote:

> I have PIX 515 w/5.3(1) IOS running and I ran into a problem with SMTP 
> connectivity between two Exchange servers.  I have the FW opened up to allow 
> SMTP between Server 1 and Server 2 and everything seemed okay.  Now here is 
> the freaky problem.  Server 1 receives inbound email just fine, but its 
> outbound email to Server 2 will sit in the queue for a random amount of time 
> before being sent.  I hooked up a Sniffer between Server 1 and the FW and 
> the majority of the traffic between the two servers showed "No Response".  
> When I decoded the traffic it looked like Server 1 was sending a reset 
> (RSET) to Server 2 and that is what was causing the problem.  After some 
> research on CCO I found an incompatibility with older PIX IOS versions and 
> the "Mailguard" feature.  It seems that the Mailguard feature didn't support 
> "ESMTP", which these Exchange servers are using.  I thought I had found the 
> problem until I did a little bit more digging and found that this was fixed 
> in IOS 5.2(2) and later with the new support of RFC 1869 for SMTP Service 
> Extensions.  So this shouldn't be an issue.  The thing that is throwing me 
> off is that A.) Inbound email to Server 1 has no problem.  B.) The server 
> admin setup a test servers and both inbound and outbound traffic worked fine 
> through the PIX.  C.) Server 2 isn't having any problems getting through the 
> FW.  Now here is the kicker...D.) When I disabled "Mailguard" everything is 
> said to be working normally!!
> 
> I might be paranoid, but I'm starting to think the Exchange guys made some 
> changes on Server 1 and are trying to lead me to believe that it was my FW, 
> but I'm having a hard time dealing with that.  The whole denial thing of 
> nothing ever going wrong with Cisco :-|, and the fact that I wasn't involved 
> in the final stage of the troubleshooting.  I don't trust many people.  
> Anyway....if anyone has ever run into this problem or something similar I 
> would like to hear your story.
> 
> TIA for all and any responses to my incoherent pleas for mercy!
> 
> Eric
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