We use Sendmail 8.13.0 (since 8.12.11) + Clamav-milter + Clamd. No quarantine, no postmaster/sender/recipient notice, just reject messages. Centralized freshclam on two servers at different times (minutes 23 and 53 respectively). OnUpdate it propagates vía sftp to the other 9 servers (including the other one that runs freshclam, so it doesn't have to update again). OnUpdate & OnError sends a message to postmaster.
You can guess our monthly stats. We have more than 4 million mails daily, 150 clamav-milter and 26 clamd threads concurrently per server on peak hour.
Damn,
That's the kind of things that makes me fell like I'm managing a coffee maker :-P
BR, Matías.
_______________________________________________ http://lists.clamav.net/cgi-bin/mailman/listinfo/clamav-users