I've had a similar problem with om. Even with the basic tutorial on their site.

To reproduce the error it's enough to create the tutorial:
    lein new mies-om om-tut

And then activate advanced optimizing. Then browser will give the error:
"Uncaught TypeError: Cannot read property 'input' of undefined"

To resolve the issue it's enough to add the react.js to the :externs section of 
the configure like this one: 
https://github.com/vladp/cljs_om_dojo/blob/master/project.clj

I intend to create an issue about this on the om repository.

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