Hi David, Sorry for the very long delay on this. I've been off the list (and off all email, actually) for a very long time - only just getting back on now.
> Date: Tue, 17 Aug 2004 02:00:59 -0000 > From: "dbradley49" <[EMAIL PROTECTED]> > Subject: Re: Richard? My latest CML and now CLL (!) Lab results > > Dear Richard, > > Thanks for your counsel! How can you tell if "the trisomies 12 and > 14 were in lymphoid (as opposed to myeloid) cells"? I thought > chromosome abnormalities were everywhere? Or at least on > undifferentiated stem cells...? I don't actually know whether BCR-ABL is detectable in other blood cell lines (it's an interesting question) - but standard cytogenetics only show the Philadelphia Chromosome in myelogenous cells, that is, in granulocytes (also known as neutrophils, or poly's - it's confusing). As to trisomies 12 and 14, I believe these are only in the lymphoid line. One possible source of confusion is the word "genetic," which many people mistakenly equate with hereditary. When you have a hereditary chromosomal change, it shows up in all your cells. With acquired genetic changes (mutations that occur during the individual's lifetime, that is), the results only show up on the progeny of the cell that underwent the mutation. Does this help? Best, Richard R ------------------------ Yahoo! Groups Sponsor --------------------~--> $9.95 domain names from Yahoo!. Register anything. http://us.click.yahoo.com/J8kdrA/y20IAA/yQLSAA/8zSolB/TM --------------------------------------------------------------------~-> New! Sign up for local CML support group meetings in your local community at http://cml.meetup.com Apply for Commercial Real Estate loans online and submit your deal to dozens of hungry lenders in just minutes. Loan programs for all types of business and commercial real estate. Apply anytime at http://realestatezoo.com CML (Chronic Myelogenous Leukemia Support List) --------------------------------- Part Of CMLHope.Com An International Community Of CML Patients For more information: http://cmlhope.com Post Message: [EMAIL PROTECTED] Subscribe: [EMAIL PROTECTED] Unsubscribe: [EMAIL PROTECTED] Change To No Mail/Web: [EMAIL PROTECTED] Change To Digest: [EMAIL PROTECTED] Change To Email: [EMAIL PROTECTED] List Help: [EMAIL PROTECTED] CML Group Web Site http://groups.yahoo.com/group/CML Yahoo! Groups Links <*> To visit your group on the web, go to: http://groups.yahoo.com/group/CML/ <*> To unsubscribe from this group, send an email to: [EMAIL PROTECTED] <*> Your use of Yahoo! Groups is subject to: http://docs.yahoo.com/info/terms/
