Hi all. Just wanted to share some thoughts on PCR trends. Most of on the List remain pcr-detectable . . . and in my latest results from MDAnderson, I am now pcr-detectable . . .although I am also 'pcr-undetectable' via OHSU (blood was drawn a week apart for these two tests)
As Anjana has frequently discussed, pcr testing is not standardized and runs the gamut of using different testing methods/housekeeping genes as well as testing sensitivity. Anjana pointed out that OHSU uses a GP6 housekeeping gene to run their pcr testing while MDAnderson utilizes a ABL housekeeping gene in their testing so it is not an 'apples to apples' comparison. However, I wanted to share my trends over the past year and half in the hopes that those of you who have gone from pcr - undetectable to detectable know that trends continue to be important and as I've learned (and lost lots of sleep over)to look at the 'big picture' and not one pcr test. Here are my quantitative pcr results since I started to do this testing: 04/03 pcr-undetectable (via MDAnderson) 07/03 pcr 0.0123 (via MDAnderson) 10/03 pcr 0.0233 (via MDAnderson) 12/03 pcr 0.0977 (via MDAnderson) 02/04 pcr-undetectable (via Saywer's Lab UCLA) 04/04 pcr-undetectable (via OHSU) 07/04 pcr 0.0141 (via MDAnderson) 7/04 pcr-undetectable (via OHSU)* * I benchmarked my results with OHSU as of there were some concerns I had about MDA's testing. I wasn't aware at the time that they use different housekeeping genes so that explains the difference per Anjana's explanation last week. My 12/03 pcr went up enough since 10/03's that I was very concerned. Dr. Giles felt there was no reason to be concerned yet and to continue on my current protocol - which is 800 mgs of IM. He said that if the trend continued to go up, we'd re-visit the issue. Fortunately, it has gone back down again. Anyway, I wanted to post and share my 'big picture' with all of you who are struggling with up and down pcrs. It's difficult to wait it out to see the 'trend' and where it's heading - especially when it's on the upswing! I suspect that my pcr's will continue to go up and back down (as will my nerves! : - ) but knowing that it's been relatively stable is key in the overall scheme of things. Hope this helps many of you also concerned about up and down pcr trends. Love, Barbara Heathcote Raleigh, NC ------------------------ Yahoo! Groups Sponsor --------------------~--> $9.95 domain names from Yahoo!. Register anything. http://us.click.yahoo.com/J8kdrA/y20IAA/yQLSAA/8zSolB/TM --------------------------------------------------------------------~-> New! Sign up for local CML support group meetings in your local community at http://cml.meetup.com Apply for Commercial Real Estate loans online and submit your deal to dozens of hungry lenders in just minutes. Loan programs for all types of business and commercial real estate. Apply anytime at http://realestatezoo.com CML (Chronic Myelogenous Leukemia Support List) --------------------------------- Part Of CMLHope.Com An International Community Of CML Patients For more information: http://cmlhope.com Post Message: [EMAIL PROTECTED] Subscribe: [EMAIL PROTECTED] Unsubscribe: [EMAIL PROTECTED] Change To No Mail/Web: [EMAIL PROTECTED] Change To Digest: [EMAIL PROTECTED] Change To Email: [EMAIL PROTECTED] List Help: [EMAIL PROTECTED] CML Group Web Site http://groups.yahoo.com/group/CML Yahoo! Groups Links <*> To visit your group on the web, go to: http://groups.yahoo.com/group/CML/ <*> To unsubscribe from this group, send an email to: [EMAIL PROTECTED] <*> Your use of Yahoo! Groups is subject to: http://docs.yahoo.com/info/terms/
