Zavie and Richard:

It isn't either/or between a qPCR and a BMA.  BMA is just one means of
obtaining testable tissue, as is venipuncture, that is drawing blood from
your arm.  Both can be tested by any sort of PCR and by FISH.  Conventional
cytogenetics is the only test that pretty much relies on BMA (because it
requires stem cells for culture and there aren't generally enough of these
in the blood stream, which mainly hosts mature blood cells).

Most or all experts agree that a BMA is a good idea from time to time no
matter what level of remission you have reached - generally yearly once
you're in CCR or better. qPCR is indeed run on the BMA aspirate, but so is
it run on peripheral blood drawn every three months.

Hope this clarifies.

Richard R   

>  Date: Tue, 21 Sep 2004 18:14:19 -0400
>  From: "Zavie Miller" <[EMAIL PROTECTED]>
> Subject: RE: QPCR
> 
> Hi Richard,
> 
> This is an initiative that Novartis has started in Canada. They are
> providing it free of charge right across Canada. I'm not sure what is in it
> for them. Possibly to help standardize PCRs for all Canadians. If this is
> the case, then I would want the identical test (same sensitivity) run over a
> number of years so that we can track the disease.
> 
> I don't believe that a QPCR replaces a BMA. Both are diagnostic tools and
> your doctor decides which one he needs done.
> 
> Zavie
> 
> 
> 
> -----Original Message-----
> From: schempp_richard [mailto:[EMAIL PROTECTED]
> Sent: September 21, 2004 4:37 PM
> To: [EMAIL PROTECTED]
> Subject: [CML] QPCR
> 
> 
> This time when I visited my onc., she had me give a blood sample to
> be sent to Montreal. Apparantly now they do a QPCR instead of the
> somewhat traumatic BMA. Is this common practice now?
>                   Richard S



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