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Lynn,
I have
been following your trials and tribulations regarding your problems with
bone pain and I came across this abstract. I might have a chance
today to find the entire article. I will send it to you when I
do. Maybe this article will help you convince your local doctors
that your pain is real and needs to be treated.
Sending
you healing thoughts and peace,
Cheryl-Anne
Review |
| Pain syndromes in haematological malignancies: an overview |
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| Pasquale Niscola1, Edoardo Arcuri2, Marco Giovannini3, Laura Scaramucci1, Claudio Romani4, Francesca Palombi5, Giulio Trap�6 and Fortunato Morabito7 |
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1Hematology Unit, ASL Viterbo, Rome, Italy 2Pain Clinic and Palliative Care Unit, IRCSS 'San Raffaele' Institute, Rome, Italy 3Hematology Unit, Umberto I Hospital, Frosinone, Cagliari, Italy 4Hematology and Transplantation Unit, Businco Hospital, Cagliari, Italy 5Division of Hematology, Sant' Eugenio Hospital, Tor Vergata University, Rome, Italy 6Division of Hematology, Catholic University, Rome, Italy 7Hematology and Transplantation Center, Bianchi-Melacrino-Morelli Hospital, Reggio Calabria, Italy |
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Correspondence to: P Niscola, Montefiascone Hospital, Deparment of Hematology, Via Verentana 23, Montefiascone Viterbo, 01027, Italy. Tel: +39 0761 8331; Fax: +39 0761 8332 65; E-mail: [EMAIL PROTECTED] |
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| Abstract |
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Several pain syndromes, which may be related to the diagnostic procedures, to the treatments, or to disease itself, may be recorded during the disease course of most haematological malignancies. So far, the painful complication occurring in this setting has been poorly investigated. Pain arising from skeletal and bone marrow (BM) involvement represents the most frequent disease-related painful states observed in this setting, while patients undergoing treatments with curative intent, such as BM transplantation, usually experienced painful stomatitis. Additionally, more than one pathologic process may coexist simultaneously in one patient and the pathophysiology of pain and hypersensitivity may change over time. An accurate diagnostic assessment and the identification of the underlying pathogenetic mechanism may dictate the treatment approach. For most patients in pain, the World Health Organisation's three-step analgesic scale provides adequate relief with oral options. Pain left unrelieved may induce an aberrant peripheral activity and central functional alterations, generating chronic neuropathic pain. In the aim to summarize the current knowledge on this topic, the pertinent literature and the current guidelines for the pain management were reviewed by a group of haematologists, experienced in palliative care and by a skilled algologist, involved as consultant in this clinical setting. The Hematology Journal (2004) 5, 293-303. doi:10.1038/sj.thj.6200530 |
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| Keywords |
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pain; hematology; hematological malignancies; leukemia; bone pain |
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| Received 5 August 2003; accepted 27 April 2004 |
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| 2004, Volume 5, Number 4, Pages 293-303 |
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