--- In [EMAIL PROTECTED], "Karen Andrews" <[EMAIL PROTECTED]> > 
My dr originally saw diahhria as just an annoyance that aggravated 
me. However, I am convinced that it is much more serious than that. 
I really think it has some impact on how well gleevec is abosorbed 
into your body. Before the diahhria started I had reached PCRU. As 
soon as the diahhria started, over 18 months, I lost my PCRU, lost 
my cytogenetic remisission, became 76% PH pos by fish and wbc 
started rising! During this 18 months, I lost all other gleevec side 
effects and started developing other cml symptoms (enlarged spleen, 
night sweats.). Since taking the immodium a month ago, my wbc is now 
back normal, I now have all of the gleevec side effects that I had 
during that 1st year, and my spleen is normal, no night sweats and I 
feel great! My dr says that it is possible that the gleevec wasn't 
being absorbed (at least not well) because of the diahhria, but I 
don't think he's as convinced as I am (yet). I have a fish and bmb 
on Nov 19 and that should show if the gleevec is now working again. 
I wrote a letter to novartis and the customer service people 
forwarded it on to their more technical scientific people, but I 
havent heard back yet.
> 
> Hang in there and I hope the immodium works.
> 
> -karen A

____________________________

Dear Karen,

I, too, am keeping my fingers crossed that your next BMB and FISH 
shows an improvement. Please keep us posted in re the absorption of 
Gleevec issue.

Warm Regards,
Kristin





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