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I am not positive, but I think Dr. Shadduck is in UPMC
(University of Pittsburgh Medical Center)
Bob
----- Original Message -----
Sent: Thursday, December 02, 2004 8:55
AM
Subject: Re: [CML] Re: 400 vs 800
mg
Hart,
You are blessed with a good sleeper! I hope she continues to sleep
well and long.
You might ask your wife's doctor to fill you in on the research being
reported at the upcoming American Society of Hematology conference (it's
happening within the next week I think). The annual ASH meeting is where
most leukemia research is reported and discussed among doctors and
scientists in the field. Any results from the trials on 800mg will be
reported there. You can also take a look at selected abstracts by going
to cmlsupport.com. If you want to look at all the abstracts, go to ASH's
website (I think it's ash.org, but I'm not sure), sign in and you can search
everything that will be presented. I can't remember where Dr. Shadduck
works, but I'm sure others on the list know him.
Good luck,
Adrienne
nin9inch9nails
<[EMAIL PROTECTED]> wrote:
Hi
Adrienne,
Thank you for your informative reply.
The baby has
been unbelievably good based upon what everyone had been
forewarning us
about. She never cries. We feed her at around 9:30pm
put her
to bed. She make some baby noises between 1 and 2 am to let
us
know she is hungry at which time we change her diaper, feed her
and
she's good until 6 am. We just can't believe how good she
is.
What
an interesting theory you have regarding the initial severity of
side
effects to treatment resulting from the body being flooded with
leukemia
cells that suddenly and massively are killed by
Gleevec��
since my
wife was pheresed all those weeks during pregnancy, maybe
her initial
reaction to Gleevec won't be so severe as her blood
and
organs have
recently been cleansed of white blood cell.
As to which clinical
trial does her doctor want her to join?
Going by memory, since I
don't have the document in front of me, the
trial centers on the
molecular response to high Gleevec doses in
patients with newly
diagnosed chronic phase CML. Verifying earlier
findings that 92%
of participants taking 800mg achieve CCR in twelve
months versus 72% of
particants taking only 400 mg. Which raises the
same question in my mind
as it did in yours as to whether on a longer
time horizon the 400mg
patients achieve the same percent CCR. Two
different curves approaching
the same asymptote over time.
The doctor named in the study is
Dr. Richard Shadduck.
Thank again for your reply and sharing the
experience your husband
had when first taking Gleevec.
Hart
Zaun
--- In [EMAIL PROTECTED], Adrienne Davis
<[EMAIL PROTECTED]> wrote:
> Hello Hart,
>
>
Congratulations to you and your wife on the birth of you baby!
Your family has a lot on its plate with the new baby, your wife's
diagnosis and beginning her treatment. I wish you many years of
enjoying your little one and hope you get as much sleep as you can;
babies are notorious for inducing major sleep deprivation.
>
> My husband began his treatment one year ago in a clinical trial
that gave him 800mg. I will tell you that the first two or three
months on the trial were rough. He had every side effect in the
book. The worst were constant diarrhea, crashing blood counts and
crippling muscle cramps. I'm not telling you this to scare you,
but
just to let you know what could happen. Everyone is
different. The
good news is that he got through that stage and his
side effects,
although there, are much, much better. My own theory
is that the
first few months are the worst because the body is flooded
with
leukemia cells that suddenly and massively are killed by
Gleevec. It
takes time for the body to rid itself of all those
dead cells and to
adjust to the presence of Gleevec. Although side
effects may
continue, they are generally much milder, and there are many
things
that can be done to minimize or eliminate them. This group
is a
wonderful source of remedies for virtually everything that
Gleevec
> can throw at you. Cmlsupport.com also has a
comprehensive list of
side effects and things that can be done for each
one. And keep in
mind that some people have only mild side effects
from the
beginning. These days Jim has mild diarrhea from time to
time,
controls his fluid retention (which virtually everyone gets to
some
degree) with Lasix and potassium and calcium supplements, has
some
mild skin rashes and stable blood counts. He hasn't had a
muscle
cramp in months.
>
> As for the underlying
theory of starting on 800mg, it's debatable.
The theory is that
more leukemia cells are killed more quickly with
800mg than 400mg.
This gets people into complete cytogenetic
responses and molecular
remissions faster and reduces the likelihood
that people will become
resistant. 800mg certainly gets people into
remission faster, but
some CML experts are skeptical that faster is
better. Some think
people will reach the same point with 400mg and
fewer side effects in
time and that resistance rates will likely be
the same with both
dosages. No one knows at this point which course
is better, which
is why there are clinical trials designed to examine
these
questions. Hope this helps. What clinical trial does her
doctor want her to join?
>
> Adrienne
>
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