--- In [EMAIL PROTECTED], rrockef1 <[EMAIL PROTECTED]> wrote:
> Hi Nanc. If your mutations showed wild type, to what do they attribute your > relative insensitivity to IM? Drug efflux? Suboptimal uptake? > > Cheers, > Richard R _______________________ Hi Richard, I thought you were going to say I was a 'wild thing' and not a 'wild type'. Actually Dr. Druker has never thought I had a mutation, and neither did Dr. Talpaz when he saw me in Feb. 2003, before mutation testing was available....from looking at my response to IM. It is not a mutation pattern. We kind of did the mutation test just to confirm this. I had a small response to 400mg (from 100% down to 80%) and then a larger response to 800mg (fluctuating between 15% and 40%)..... but I have never lost my response. The variation I have up and down is within the margin of error of cyto testing. Make sense? Dr. Druker says I have a primary resistance (or decreased sensitivity)to IM, and that the causes of this are not well understood. Also, those who never get a cyto response and stay at 100% ph+ but have stable disease are probably in this category. He mentioned possibilities like a pump that pushes IM out of the cell or out of the nucleus, etc. The expectation (or hope) is that when I am on a more potent drug, I will get a better response...and they are seeing some people who have never had a cyto response, getting a response with BMS. This is different than the acquired resistance that you get with mutations. Here, someone might be 23% ph+, then 3 or 6 months later up to 75% ph+.....this pattern looks more like a mutation...the response changed. My response is stable, just not complete. Maui Nanc ------------------------ Yahoo! Groups Sponsor --------------------~--> $4.98 domain names from Yahoo!. Register anything. http://us.click.yahoo.com/Q7_YsB/neXJAA/yQLSAA/8zSolB/TM --------------------------------------------------------------------~-> New! Sign up for local CML support group meetings in your local community at http://cml.meetup.com Apply for Commercial Real Estate loans online and submit your deal to dozens of hungry lenders in just minutes. Loan programs for all types of business and commercial real estate. Apply anytime at http://realestatezoo.com CML (Chronic Myelogenous Leukemia Support List) --------------------------------- Part Of CMLHope.Com An International Community Of CML Patients For more information: http://cmlhope.com Post Message: [EMAIL PROTECTED] Subscribe: [EMAIL PROTECTED] Unsubscribe: [EMAIL PROTECTED] Change To No Mail/Web: [EMAIL PROTECTED] Change To Digest: [EMAIL PROTECTED] Change To Email: [EMAIL PROTECTED] List Help: [EMAIL PROTECTED] CML Group Web Site http://groups.yahoo.com/group/CML Yahoo! Groups Links <*> To visit your group on the web, go to: http://groups.yahoo.com/group/CML/ <*> To unsubscribe from this group, send an email to: [EMAIL PROTECTED] <*> Your use of Yahoo! Groups is subject to: http://docs.yahoo.com/info/terms/
