Hi Mark,
Thanks for taking the time to share with us your notes on ASH. You bring up an interesting point that I've also thought of often. Like you, I took Hydrea for a month before starting Gleevec and in that month, my WBC normalized. I really wish someone would have thought to do a PCR on diagnosis so that I could have a more accurate target of what I've achived but I guess I can't cry over spilt milk. In any case, what I find confounding is that while we would assume that plenty of phillies are being killed during Hydrea treatment, it is also known that good cells are also being eliminated with Hydrea so how could we know in what proportion are the good and the bad being targeted? Therefore, without an official PCR number, I don't know if we can assume any type of log reduction with Hydrea alone. Here's another thought that occured to me: for someone who started out with a very heavy leukemic load and achived the famous 3 log reduction, we know this fairs well. Now how about the person who started out with a very small leukemic load (because their disease was caught so early) and only achived a 1 or 2 log reduction from baseline. The end leukemic load in the second person may infact be smaller than the first yet the reduction wasn't as impressive so how would that correspond with PFS stats? I'm just thinking out loud here. There may be a simple answer that I haven't thought of or there may not be an answer at all. In any case, thanks again for your time and please continue to share with us as much as you can. Take care, Tracey --- In [EMAIL PROTECTED], "mpetersen123" <[EMAIL PROTECTED]> wrote: > > > Hi Richard, >> You also brought up an interesting point about the log reduction due > to simply gaining a hematalogic response. We tend to think along the > lines of IM-only therapy when discussing log reductions but many > patients are initially treated with Hydrea. In my case for example, > I had a full log reduction hematologically just due to hydrea alone. > This implies that newly diagnosed patients should have their PCR test > performed at initial diagnosis rather than at initial treatment for > Gleevec. ------------------------ Yahoo! Groups Sponsor --------------------~--> Make a clean sweep of pop-up ads. Yahoo! Companion Toolbar. Now with Pop-Up Blocker. Get it for free! http://us.click.yahoo.com/L5YrjA/eSIIAA/yQLSAA/8zSolB/TM --------------------------------------------------------------------~-> New! Sign up for local CML support group meetings in your local community at http://cml.meetup.com Apply for Commercial Real Estate loans online and submit your deal to dozens of hungry lenders in just minutes. Loan programs for all types of business and commercial real estate. Apply anytime at http://realestatezoo.com CML (Chronic Myelogenous Leukemia Support List) --------------------------------- Part Of CMLHope.Com An International Community Of CML Patients For more information: http://cmlhope.com Post Message: [EMAIL PROTECTED] Subscribe: [EMAIL PROTECTED] Unsubscribe: [EMAIL PROTECTED] Change To No Mail/Web: [EMAIL PROTECTED] Change To Digest: [EMAIL PROTECTED] Change To Email: [EMAIL PROTECTED] List Help: [EMAIL PROTECTED] CML Group Web Site http://groups.yahoo.com/group/CML Yahoo! Groups Links <*> To visit your group on the web, go to: http://groups.yahoo.com/group/CML/ <*> To unsubscribe from this group, send an email to: [EMAIL PROTECTED] <*> Your use of Yahoo! Groups is subject to: http://docs.yahoo.com/info/terms/
