Hi Giora, Yup, we can confirm this. Cheryl-Anne noticed it first and pointed it out to me. Dr. Talpaz was sitting about 4 rows in front of us and was dutifully taking notes. It was good to see. Regards, Mark --- In [EMAIL PROTECTED], "giora1" <[EMAIL PROTECTED]> wrote: > hallo mark > thanks so much for your summary. its great. > i just spoke to one of the israeli representatives who came back from the ash and i heard an interesting remark concerning drs at the ash. > he mentioned that he sat next to dr talpaz who was attending many of the presentations and was sitting and taking notes from other drs presentations like a yound student. he also mentioned that dr talpaz was one of the very few to do it. > it only shows no matter how expert you are you still learn from others. the problem is that many drs dont realize it. > shalom > giora > ----- Original Message ----- > From: mpetersen123 > To: [EMAIL PROTECTED] > Sent: Sunday, December 12, 2004 8:13 AM > Subject: [CML] Re: Newbie ASH Summary (1/3) - Intro - Gay, Nancy, Richard T, Wayne, Allen > > > > > Thanks everyone for the complements. I hope the summary is useful to > some. Unfortunately it took longer to post than I wanted, so much of > what was discussed is probably old hat by now. Having it summarized > might be useful though. > > Nancy, you brought up a good point about CML being targeted because > it's simple and so well understood. When I was first diagnosed my > oncologist said that everyone with CML has the same exact disease > (the ph chromosome). He said that if you examine 1,000 breast cancer > patients you'll see 1,000 different cancers. Another example of this > was an AML session that Cheryl-Anne and I sat through (it came after > a CML session). The topic was inhibition targets for AML. Talk > about a complex disease. It was easily 10x more complicated than > CML. There were at least a dozen or so pathways that were discussed, > apparently all of which are active in AML. It's clear that a cure > for something like AML will be far more difficult. > > Also, thanks for bringing up the LLS. I forgot to mention that the > LLS sponsored a lot of the BMS-354825 research. Very cool! > > Lastly, as far as Dr. Druker is concerned. Meeting him was really a > high point for me at ASH. Many of those who presented are > essentially clinicians who see a lot of CML patients and can comment > on various studies and the statistics of various things. Both Dr. > Druker and Dr. Sawyers have impressed me because in addition to being > clinicians they are both high powered scientists. In addition, Dr. > Druker also struck me as a good person whose work is all about > putting the patients first. I'm envious now of those of you who are > patients who see Dr. Druker. > > Regards, > Mark > > > > --- In [EMAIL PROTECTED], "hey00nanc" <[EMAIL PROTECTED]> wrote: > > > > --- In [EMAIL PROTECTED], "mpetersen123" <[EMAIL PROTECTED]> > wrote: > > > > > > > > > A few people have asked me to post a newbie ASH summary because > of > > my > > > perspective as a 6 month newly diagnosed CML patient. So I > figured > > > that I would sit down and write about the topics that I found > > > interesting and of the most importance. > > > > ________________ > > > > Thanks Mark, > > You did a really great job with your summary, with the special > little > > bits of info that you gleaned from some of the 'biggies' and your > own > > interpretation, based on lots of personal research. And I'm glad > that > > you also had fun! > > > > My few comments: > > There is a reason that there is so much research into CML and that > a > > race for the cure is on. It wasn't just 'luck' for us. CML is > probably > > the simplest cancer there is....where almost all cmlers in early > > chronic phase have just the same, well understood chromosomal > > abnormality, the ph+ chromosome. Of course, we know it is not quite > as > > simple as that...there are those who have what we call the standard > > 'garden variety' cml and those who have something a bit different, > > like translocations between 3 chromosomes, etc. But in comparison > > between what is known about other cancers and what is known about > cml, > > there is a huge difference. So, it makes sense to work on the > simplest > > cancer first....this should be the one that is the easiest to > solve, > > the easiest to cure. Curing a cancer would be any researcher's > dream! > > We lucked out! > > > > Here I will add my thanks to all of those on this list who have > been > > fund raisers for the Leuk & Lym Society, with their participation > in > > teams in training marathons, etc. This society has funded a lot of > the > > research, including the collaboration between Druker and Sawyers in > > researching the mollecular pathways and detecting mutations. > > > > Personally, I was interested in your comments about early > resistance > > and the 'wild type'. I will review all the previous notes for when > I > > see Dr. Druker in early January and we talk about my next best > option. > > > > And lastly I wanted to comment on your impression that Dr. Druker > was > > more reserved about the potential of BMS than Dr. Sawyers.....Dr. > > Druker always wants statistically significant scientific proof > first, > > but I expect that he is enthusiastic under the surface. I will let > you > > know if I see another side when I have my follow-up. > > > > The question with Gleevec has been, why can it get so many to CCR > (I > > think maybe about 97% of the newly diagnosed).......but so few to > > PCRU (maybe 5-10%)? We hope that these new more potent drugs will > take > > people to a higher level of response. > > > > Thanks again Mark for all your sharing. > > Maui Nanc > > > > > > New! Sign up for local CML support group meetings in your local community at http://cml.meetup.com > > Apply for Commercial Real Estate loans online and submit your deal to dozens of hungry lenders in just minutes. Loan programs for all types of business and commercial real estate. Apply anytime at http://realestatezoo.com > > CML (Chronic Myelogenous Leukemia Support List) > --------------------------------- > Part Of CMLHope.Com > An International Community Of CML Patients > For more information: http://cmlhope.com > > Post Message: [EMAIL PROTECTED] > Subscribe: [EMAIL PROTECTED] > Unsubscribe: [EMAIL PROTECTED] > Change To No Mail/Web: [EMAIL PROTECTED] > Change To Digest: [EMAIL PROTECTED] > Change To Email: [EMAIL PROTECTED] > List Help: [EMAIL PROTECTED] > CML Group Web Site http://groups.yahoo.com/group/CML > > > > Yahoo! Groups Sponsor > > Get unlimited calls to > > U.S./Canada > > > > > -------------------------------------------------------------------- ---------- > Yahoo! Groups Links > > a.. To visit your group on the web, go to: > http://groups.yahoo.com/group/CML/ > > b.. To unsubscribe from this group, send an email to: > [EMAIL PROTECTED] > > c.. Your use of Yahoo! Groups is subject to the Yahoo! Terms of Service. ------------------------ Yahoo! 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