Re: [CML] Houston, we have a problem...cytos

[Rob]

Dane,   The new drugs are having tremendous success with so many patients so there are still a lot of options and MDACC is one of the best places to be.   Rob   ----- Original Message ----- From: Dane T. To: CML@yahoogroups.com Sent: Monday, December 27, 2004 4:14 PM Subject: [CML] Houston, we have a problem...cytos I received my first set of cytos since relapsing.  The news is not great.... Looks like I will be back in Houston sooner than expected. > Dear Mr. Tessler: > > I have attached the cytogenetics results below: > > Ph+ clone 48,XY,+8,+8,t(9;22)(q34;q11.2)[11] >                   2 metaphases photographed/karyotyped > > Diploid male karyotype 46,XY[9] >                   2 metaphases photographed/karyotyped > > Although the number of abnormal metaphases is less than has been the case > before, there are additional cytogenetic changes consistent with clonal > evolution in addition to the Philadalephia chromosome (i.e. clonal > evoluation consistent with accelerated phase). The options are to continue > with the combination as is (after all you only have been treated for 3 > cycles), OR to try a different approach such with one of the newer > tyrosine > kinase inhibitors (e.g. AMN107). Personally, I prefer the latter. I have > already put out my feelers with the research nurse of the AMN protocol. If > you wanted to consider this as well, we should get you back earlier, like > next week. Also you would have to be off imatinib and any additional > investigational agents. Let me know what you think. New! Sign up for local CML support group meetings in your local community at http://cml.meetup.com Apply for Commercial Real Estate loans online and submit your deal to dozens of hungry lenders in just minutes. Loan programs for all types of business and commercial real estate. Apply anytime at http://realestatezoo.com CML (Chronic Myelogenous Leukemia Support List) --------------------------------- Part Of CMLHope.Com An International Community Of CML Patients For more information: http://cmlhope.com Post Message: cml@yahoogroups.com Subscribe:  [EMAIL PROTECTED] Unsubscribe:  [EMAIL PROTECTED] Change To No Mail/Web: [EMAIL PROTECTED] Change To Digest: [EMAIL PROTECTED] Change To Email: [EMAIL PROTECTED] List Help: [EMAIL PROTECTED]  CML Group Web Site http://groups.yahoo.com/group/CML New! Sign up for local CML support group meetings in your local community at http://cml.meetup.com Apply for Commercial Real Estate loans online and submit your deal to dozens of hungry lenders in just minutes. Loan programs for all types of business and commercial real estate. Apply anytime at http://realestatezoo.com CML (Chronic Myelogenous Leukemia Support List) --------------------------------- Part Of CMLHope.Com An International Community Of CML Patients For more information: http://cmlhope.com Post Message: cml@yahoogroups.com Subscribe:  [EMAIL PROTECTED] Unsubscribe:  [EMAIL PROTECTED] Change To No Mail/Web: [EMAIL PROTECTED] Change To Digest: [EMAIL PROTECTED] Change To Email: [EMAIL PROTECTED] List Help: [EMAIL PROTECTED]  CML Group Web Site http://groups.yahoo.com/group/CML Yahoo! Groups Sponsor ADVERTISEMENT Yahoo! Groups Links To visit your group on the web, go to: http://groups.yahoo.com/group/CML/   To unsubscribe from this group, send an email to: [EMAIL PROTECTED]   Your use of Yahoo! Groups is subject to the Yahoo! Terms of Service.