Hello Hottuna,

Yes it is o.k. to split your dose of Gleevec as you mentioned.  
Personally, after being at ASH and hearing how the maximum daily dose 
wasn't really determined during the clinical trials, 600 mg's is a 
pretty good dose to be on.

Travelling for so long in the car is a problem.  When I take long car 
trips I usually stop and exercise every two hourse or so.  You might 
also be having trouble with fluid retention, make sure you drink lots 
of water and ask your Dr for a mild diuretic.  If you are 
experiencing diarrhea, you can try immodium - but speak to your 
doctor about this.  I am not a Dr, do not even play one on T.V. ;>), 
these are just suggestions to help you get through the initial period 
of increasing your dose.  Some people notice that after a while the 
side effects go away, or become less apparent.

Keep us posted,
Cheers,
Cheryl-Anne



 "hottuna_au" <[EMAIL PROTECTED]> wrote:
> 
> Happy New Year to all.
> I have been increased to a dose of 600mg about 2 weeks ago due to a 
> small increase in my PH+ from 2.5% to 5 %. Since then I have 
decided 
> to instal a library in the toilet ;-)
> I have found it very dificult to keep the 600mg dose down, so have 
> started spliting the dose to 400mg in the morning and 200mg in the 
> evening. Is this OK to do?
> My only other concern is a numb patch on my upper left thigh about 
> 1.5 inches across, the same feeling your face gets after a visit to 
> the dentist. I have just gotten back from my xmas holidays and 
spent 
> 24 hours in the car over 2 days travelling home. My feet swelled up 
> like balloons, I don't know if any of this is related





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