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Antiangiogenic gene therapy offers an attractive approach to the treatment
of a variety of malignancies, including those of the hematological system.
However, evaluation of this approach has been hampered by the lack of
appropriate animal models. We have recently produced transgenic mice expressing
P230 bcr/abl that develop myeloproliferative disease (MPD) closely resembling
human chronic myelogenous leukemia.
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