Nan, All I can tell you is in my last conversation with my onc what I 'THINK' I understood is that he wants the blasts at 0%, which would be a better indicator for longer remission and less chance for a mutation to occur. However, I'm only 6 mth into this disease so I could have misunderstood what he was saying. I go back in April for another bmb/bma and I plan to probe him a little more.
I welcome any veterans in the group to jump in and give their thoughts. Am I way off? Besides blast % helping to determine what phase of CML your in what else do they help measure/track? Brenda --- In [email protected], "nanny_net2000" <[EMAIL PROTECTED]> wrote: > > Hi Cheryl Anne and Brenda > Not sure I am understanding this at all, so forgive me if I have > read it completely incorrectly. > Rich is 100% PH+ since losing response to Glivec in May 2004. > Discovered he has M244V P Loop Mutation, yet his blasts are only 1%. > Figures still have him in chronic phase, but consultant concerned he > was on verge of accelerated phase due to the grouping of the blasts, > as opposed to numbers. Currently on Hydrea and awaiting BMS in > London, UK. > Can you explain this article any further ? Hope I am not being > dense. > Love to you both > Annette > > > --- In [email protected], "Brenda Morelli" <[EMAIL PROTECTED]> wrote: > > > > Thanks Cheryl Anne, > > This helps me understand why my onc was only semi happy about my > > results, though I was 0 PH+ and PCR at .4%, my myloid blasts had > only > > dropped from 3% to 2% after 6 mths. That's what he wanted to see > at > > 0%, he had said that once blasts are at zero there is longer > > remission hold AND less chance of mutation. > > Brenda > > > > > > --- In [email protected], "Cheryl-Anne Simoneau" > > <[EMAIL PROTECTED]> wrote: > > > Blast count and cytogenetics correlate and are useful parameters > > for the > > > evaluation of different phases in chronic myeloid leukemia. > > > > > > Bacher U, Kern W, Schnittger S, Hiddemann W, Schoch C, Haferlach > T. > > > > > > Staging of chronic myeloid leukemia (CML) phases is based on > > > cytomorphological criteria that vary considerably between > different > > staging > > > systems. Thus, staging of CML is heterogeneous and causes > problems > > with > > > respect to the comparison of therapeutical strategies and > clinical > > outcome. > > > We evaluated 59 patients with CML in different stages of the > > disease. In > > > order to define which cytomorphological parameters correlate with > > > cytogenetics we investigated cytomorphology and cytogenetics in > > parallel in > > > all cases. As a result, bone marrow blast count demonstrated a > > highly > > > significant correlation with the respective cytogenetic results > of > > the > > > patients and was clearly linked to the frequency and complexity > of > > clonal > > > evolution. We therefore propose to focus staging systems of CML > on > > the > > > correlation of the percentage of bone marrow blasts and the > > cytogenetic > > > results. ------------------------ Yahoo! Groups Sponsor --------------------~--> Add meaning to your holidays. Help save a child's life by supporting St. Jude's 'Thanks & Giving.' http://us.click.yahoo.com/2iazvD/7WnJAA/xGEGAA/8zSolB/TM --------------------------------------------------------------------~-> New! Sign up for local CML support group meetings in your local community at http://cml.meetup.com Apply for Commercial Real Estate loans online and submit your deal to dozens of hungry lenders in just minutes. Loan programs for all types of business and commercial real estate. Apply anytime at http://realestatezoo.com CML (Chronic Myelogenous Leukemia Support List) --------------------------------- Part Of CMLHope.Com An International Community Of CML Patients For more information: http://cmlhope.com Post Message: [email protected] Subscribe: [EMAIL PROTECTED] Unsubscribe: [EMAIL PROTECTED] Change To No Mail/Web: [EMAIL PROTECTED] Change To Digest: [EMAIL PROTECTED] Change To Email: [EMAIL PROTECTED] List Help: [EMAIL PROTECTED] CML Group Web Site http://groups.yahoo.com/group/CML Yahoo! Groups Links <*> To visit your group on the web, go to: http://groups.yahoo.com/group/CML/ <*> To unsubscribe from this group, send an email to: [EMAIL PROTECTED] <*> Your use of Yahoo! Groups is subject to: http://docs.yahoo.com/info/terms/
