Thanks, Cheryl-Anne I look forward to reading your take on the full article. I will ask the consultant about the "grouping" of blasts, although I think his concern was that they were clustered together rather than scattered, as he had expected to see under the microscope. Also I recall he mentioned a cml marker (?) was at 4% instead of the expected normal percentage, which I assume would be lower.... getting out of my depth here and just hoping Rich will be on BMS very very soon. Lots of love Annette
--- In [email protected], "cher111376" <[EMAIL PROTECTED]> wrote: > > Hi Annette, > > In the case of your husband Richard, 1% blasts is quite small. In > fact most of us have at least 1% blast at Dx, and most of us are > 100% Ph+ at Dx as well. I think the bigger concern is the P loop > mutation, but we know the BMS drug has shown effectiveness against > this particular type of mutation. I would be inclined to ask the Dr > what he means by the "grouping of the blasts". That isn't > terminology I have heard before. > > The points that I got from this abstract, and I will probably get > the full article later this week, maybe tomorrow, is that it looks > at the number of blasts and the cytogenetics instead of just relying > on the sokal score system. I posted this abstract because I found > that this was in contrast to what was stated at ASH. At ASH we > heard that the sokal scoring system was still quite relevant as a > good guide for staging the phase of CML. > > I'll be as excited as the rest of us to read the rest of this paper > to see if it sheds anymore light on the situation for us. > > Hope this helps, > > Cheers, > Cheryl-Anne > <[EMAIL PROTECTED]> wrote: > > > > Hi Cheryl Anne and Brenda > > Not sure I am understanding this at all, so forgive me if I have > > read it completely incorrectly. > > Rich is 100% PH+ since losing response to Glivec in May 2004. > > Discovered he has M244V P Loop Mutation, yet his blasts are only > 1%. > > Figures still have him in chronic phase, but consultant concerned > he > > was on verge of accelerated phase due to the grouping of the > blasts, > > as opposed to numbers. Currently on Hydrea and awaiting BMS in > > London, UK. > > Can you explain this article any further ? Hope I am not being > > dense. > > Love to you both > > Annette > > > > > > --- In [email protected], "Brenda Morelli" <[EMAIL PROTECTED]> > wrote: > > > > > > Thanks Cheryl Anne, > > > This helps me understand why my onc was only semi happy about my > > > results, though I was 0 PH+ and PCR at .4%, my myloid blasts had > > only > > > dropped from 3% to 2% after 6 mths. That's what he wanted to > see > > at > > > 0%, he had said that once blasts are at zero there is longer > > > remission hold AND less chance of mutation. > > > Brenda > > > > > > > > > --- In [email protected], "Cheryl-Anne Simoneau" > > > <[EMAIL PROTECTED]> wrote: > > > > Blast count and cytogenetics correlate and are useful > parameters > > > for the > > > > evaluation of different phases in chronic myeloid leukemia. > > > > > > > > Bacher U, Kern W, Schnittger S, Hiddemann W, Schoch C, > Haferlach > > T. > > > > > > > > Staging of chronic myeloid leukemia (CML) phases is based on > > > > cytomorphological criteria that vary considerably between > > different > > > staging > > > > systems. Thus, staging of CML is heterogeneous and causes > > problems > > > with > > > > respect to the comparison of therapeutical strategies and > > clinical > > > outcome. > > > > We evaluated 59 patients with CML in different stages of the > > > disease. In > > > > order to define which cytomorphological parameters correlate > with > > > > cytogenetics we investigated cytomorphology and cytogenetics > in > > > parallel in > > > > all cases. As a result, bone marrow blast count demonstrated a > > > highly > > > > significant correlation with the respective cytogenetic > results > > of > > > the > > > > patients and was clearly linked to the frequency and > complexity > > of > > > clonal > > > > evolution. We therefore propose to focus staging systems of > CML > > on > > > the > > > > correlation of the percentage of bone marrow blasts and the > > > cytogenetic > > > > results. ------------------------ Yahoo! Groups Sponsor --------------------~--> Give the gift of life to a sick child. Support St. Jude Children's Research Hospital's 'Thanks & Giving.' http://us.click.yahoo.com/3iazvD/6WnJAA/xGEGAA/8zSolB/TM --------------------------------------------------------------------~-> New! Sign up for local CML support group meetings in your local community at http://cml.meetup.com Apply for Commercial Real Estate loans online and submit your deal to dozens of hungry lenders in just minutes. Loan programs for all types of business and commercial real estate. Apply anytime at http://realestatezoo.com CML (Chronic Myelogenous Leukemia Support List) --------------------------------- Part Of CMLHope.Com An International Community Of CML Patients For more information: http://cmlhope.com Post Message: [email protected] Subscribe: [EMAIL PROTECTED] Unsubscribe: [EMAIL PROTECTED] Change To No Mail/Web: [EMAIL PROTECTED] Change To Digest: [EMAIL PROTECTED] Change To Email: [EMAIL PROTECTED] List Help: [EMAIL PROTECTED] CML Group Web Site http://groups.yahoo.com/group/CML Yahoo! Groups Links <*> To visit your group on the web, go to: http://groups.yahoo.com/group/CML/ <*> To unsubscribe from this group, send an email to: [EMAIL PROTECTED] <*> Your use of Yahoo! Groups is subject to: http://docs.yahoo.com/info/terms/
