Richard,

Thanks for the detailed response!

I have been playing basketball on the day of the first test and 
then the day before the second.  I am holding off from any more 
excercise (except to shovel snow) till I see the neup... nefrol... 
oh hell - the kidney specialist on Tuesday

All the best!

Chris

--- In [email protected], rrockef1 <[EMAIL PROTECTED]> wrote:
> Hi Cheryl Anne and Chris,
> 
> Creatinine is a muscle breakdown product which is exclusively 
cleared from
> the body by the kidneys.  Unlike BUN (blood urea nitrogen), which 
waxes and
> wanes with kidney perfusion (how well hydrated you are, that is), 
creatinine
> builds up more slowly and is therefore a moderately good indicator 
of kidney
> function, not just of hydration.  There are exceptions though, the 
main one
> being, as Cheryl-Anne says, when you exercise especially hard (or 
whack a
> muscle, for that matter).  Then, a lot of muscle protein can end 
up in your
> serum and since it's cleared at a steady rate, it can show up 
elevated on
> the metabolic panel.
> 
> I have wondered whether IM affects kidney function though.  
Curiously, my
> creatinine was high-normal and sometimes even a little elevated 
the first
> couple of years I was on the drug, though it's been in the mid-
normal range
> ever since.  My BUN is often high, but I think that's because I 
don't drink
> enough water when I exercise.
> 
> Cheers,
> Richard R
> 
> >  Date: Fri, 21 Jan 2005 15:10:51 -0000
> >    From: "cher111376" <[EMAIL PROTECTED]>
> > Subject: Re: Elevated Creatinine
> > 
> > 
> > Hi Chris,
> > 
> > As you know, I am not a doctor and maybe Richard R will chime in 
on
> > this one.  I think that higher creatinine levels has something 
to do
> > with dehydration.  Have you been keeping up on your fluid intake?
> > Another reason for higher creatinine levesl would be weight 
training
> > and increase in sports and phsycial activity.
> > 
> > I know of someone recently on gleevec who had higher creatinine
> > levels and increased their fluid intake.  On the next test the 
levels
> > were back to normal.
> > 
> > Hope this helps and please keep us posted,
> > 
> > Cheers,
> > Cheryl-Anne








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