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Annette,
I was really surprised that they were able to develop a drug that
will cover all of the mutations so quickly. That is a good sign that things are
moving very fast in CML treatments.
Rob
----- Original Message -----
Sent: Tuesday, January 25, 2005 1:14
AM
Subject: [CML] Re: New Drug ON012380
Overcomes All Known CML Mutations
Dear Rob, this is fabulous news, so exciting.
Come on FDA, give it
approval for clinical trials quickly. People with
T315I need this
now.
Best wishes
Annette
--- In [email protected], "Rob" <[EMAIL PROTECTED]...> wrote:
> Temple
University researchers have developed a new drug that could
potentially
treat all forms of Gleevec-resistant chronic myelogenous
leukemia (CML).
Their work is published in this week's early edition
of Proceedings of the
National Academy of Sciences...Recently, two
experimental drugs were found
to be effective in circumventing some
but not all forms of Gleevec
resistance. Both, for instance, failed
to block the activity of a mutant
BCR-ABL, called T315I, which is
one of the more predominant mutations seen
in Gleevec-resistant
patients. Reddy and his research team sought instead
to develop a
drug that would circumvent all of the mutations and therefore
all
forms of resistance....when patients become resistant to Gleevec,
our drug kills 100 percent of the cancer cells," said Reddy.
>
> http://cmlsupport.blogspot.com/2005/01/new-leukemia-drug-shows-
promise-in.html
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