Dear Dianne,
I am sorry, also, that your results are disappointing. You are doing the right thing by being proactive and it is fortunate that there are several options for you, the easiest being an increase in your dose of IM. I just wanted to mention a thought that I and others have brought up before. You may want to have mutations testing done in the kinase domain to determine the mechanism of Gleevec resistance. As long as it is not the T315I mutation, there is a good chance that the BMS drug will work very well for you. In some cases, an increase in Gleevec dose may overcome resistance or at the very least buy some time. Knowing the mutation will help you make some informed decisions and get a head start on the best option. Best of luck to you. Warm regards, Kelly --- In [email protected], "sylvain571" <[EMAIL PROTECTED]> wrote: > > Dear Diane, > > I am sorry to hear of this change for you! You have been doing so > well for so long! Former Turtle Queen :-) > Feeling shaky is certainly understandable at this point in your > journey but you are in the best of hands with Talpaz to guide you. > > Will you try the 800 mg? I seem to remember you've had lots of side > effects to manage over time since the STI trials but that over time > you have found ways to manage and do quite well!?! > > The good news is the BMS drug and AMN are arriving so you can step > over to the best one for you it if you need to. > > Hang in there. > > The current turtle Queen, > Christine > dx 11/98 > still 100%ph+ > > > Nancy,and friends who have been following our stories..... > > I just got the word from Dr. Talpaz and I must admit that I'm a > bit > > disappointed. After visiting him, I felt so good. Now, I feel > like > > a just got a kick in the butt! Only 5 of the 20 cells analyzed > were > > negative which means resistance to Gleevec is definately a > > possibility. My molecular studies show a high level of disease, > also. > > He has suggested trying to take 800 mg. to see if it's a real > issue > > of resistance. I will return in July. I guess I must seriously > start > > considering other options - BMS being 1st on my list. I would > love > > to hear from others who have been down this road. I'm a bit > shaken. > > Dianne ------------------------ Yahoo! Groups Sponsor --------------------~--> Give the gift of life to a sick child. Support St. Jude Children's Research Hospital's 'Thanks & Giving.' http://us.click.yahoo.com/3iazvD/6WnJAA/xGEGAA/8zSolB/TM --------------------------------------------------------------------~-> New! Sign up for local CML support group meetings in your local community at http://cml.meetup.com Apply for Commercial Real Estate loans online and submit your deal to dozens of hungry lenders in just minutes. Loan programs for all types of business and commercial real estate. Apply anytime at http://realestatezoo.com CML (Chronic Myelogenous Leukemia Support List) --------------------------------- Part Of CMLHope.Com An International Community Of CML Patients For more information: http://cmlhope.com Post Message: [email protected] Subscribe: [EMAIL PROTECTED] Unsubscribe: [EMAIL PROTECTED] Change To No Mail/Web: [EMAIL PROTECTED] Change To Digest: [EMAIL PROTECTED] Change To Email: [EMAIL PROTECTED] List Help: [EMAIL PROTECTED] CML Group Web Site http://groups.yahoo.com/group/CML Yahoo! Groups Links <*> To visit your group on the web, go to: http://groups.yahoo.com/group/CML/ <*> To unsubscribe from this group, send an email to: [EMAIL PROTECTED] <*> Your use of Yahoo! Groups is subject to: http://docs.yahoo.com/info/terms/
