Richard, I agree with you, my personal take is you don't need to fix it if it's not broken. I personally wouldn't want to increase the dosage unless it was necessary due to resistance or mutation. I would also think that leaving that increase dosage window open would allow for me down the road should I become resistant to 400 mg. that an increased dosage might help. It's all about getting the most time on the medicine as you can, giving the medical field time to find a that cure. I also think the risk for long term side effects would be greater with increased dosage. I guess time will only tell with all of this, we're all making history as we speak. Brenda --- In [email protected], Richard Rockefeller <[EMAIL PROTECTED]> wrote: > Hi Meghan, > > With that rapid and complete a response, increasing to > 800 mg doesn't make much sense to me. Though we may > get cured of this disease by one of the new anti-CML > wonder drugs, IM isn't curative so far and it's not > all that unlikely that we'll have to be on it for > years. If that's true, and if some people such as > yourself may no longer have to worry much about dying > from CML, then the question arises (discussed often on > this list, but not very recently) what long-term > administration of this powerful drug will do to us. > This wouldn't be so much of an issue if IM were just > going to prolong our lives by a couple of years, but > if we can now reasonably expect to live for several > more decades (depending on our age at diagnosis, of > course) then the question of preventing long-term > adverse consequences begins to take on real > importance. At present there are no hints of such > consequences, but it's not unlikely that some may > exist. If they do, then it's logical to suppose that > a higher dose is more likely to cause them than a > lower dose. > > So while I strongly support higher doses for slow > responders or for those with other risk factors, it > doesn't make sense to me to add more medication for > unknown and probably marginal (at best) benefits, > while increasing unknown but not unlikely risks! > > I know this is wordy, but I hope it's clear. > > I also want to add the disclaimer that this is just > one non-CML-specialist's opinion, and should be taken > in that light! > > All the best, > Richard > > > > > > Message: 9 > > Date: Tue, 25 Jan 2005 04:41:41 -0000 > > From: "meghannbell78" <[EMAIL PROTECTED]> > > Subject: Update of my recent QPCR... > > > > > > It has taken me a while to report the results of my > recent PCR test, > > but I have good news to report (at least I think > so). Since I don't > > post very often, I will give a quick re-cap of my > history. I am 26 > > years old and was diagnosed on August 17, 2004 in > the very early > > stages of CML. My first PCR test, which was done in > September came > > back 40% leukemic cells. On December 23, 2004, my > three month PCR > > test (on peripheral blood) came back 0.000%. I was > very excited to > > hear the news, although I do question it. I haven't > seen my doctor > > since the test, so all I heard from him was the good > news. I see him > > this Thursday for my monthly check-up. Is there > anything I should be > > questioning about the good results? I guess part of > me feels like it > > is too go to be true. I feel like I want to wait to > feel comfortable > > until I have my 6 month bmb to really know what is > going on at the > > marrow level. But I guess I have every reason to > believe that the > > Gleevec is working, so for that I am very thankful. > I am feeling so > > much better physically than I was 3 months ago. I > have regained my > > energy (for the most part), and my side effects have > almost all > > dimished. I am currently taking 600 mg of Gleevec > and despite my > > good results, my doctor would still like me to up > the dose to 800 > > mg. Does this make sense to anyone? I am hesitant > and I keep telling > > him I want to wait to see my results of the bmb in > March, but is > > this smart? I just finally feel good and have > mastered my daily > > gleeve schedule and I really don't want to have to > increase it. > > > > As my life gets more and more back to normal these > days, I find it > > harder and harder to keep up with everyone's posts, > but wanted you > > all to know how much I appreciate this group. Those > first few months > > were very hard, and now as time goes on I realize > that life does get > > back to normal and that this disease doesn't define > me. It has > > changed me, but doesn't define me. > > > > Take care, > > Meghann > > > > dx - 8.17.04 > > QPCR - 0.000% 12.23.04
------------------------ Yahoo! Groups Sponsor --------------------~--> Give the gift of life to a sick child. Support St. Jude Children's Research Hospital's 'Thanks & Giving.' http://us.click.yahoo.com/3iazvD/6WnJAA/xGEGAA/8zSolB/TM --------------------------------------------------------------------~-> New! Sign up for local CML support group meetings in your local community at http://cml.meetup.com Apply for Commercial Real Estate loans online and submit your deal to dozens of hungry lenders in just minutes. Loan programs for all types of business and commercial real estate. Apply anytime at http://realestatezoo.com CML (Chronic Myelogenous Leukemia Support List) --------------------------------- Part Of CMLHope.Com An International Community Of CML Patients For more information: http://cmlhope.com Post Message: [email protected] Subscribe: [EMAIL PROTECTED] Unsubscribe: [EMAIL PROTECTED] Change To No Mail/Web: [EMAIL PROTECTED] Change To Digest: [EMAIL PROTECTED] Change To Email: [EMAIL PROTECTED] List Help: [EMAIL PROTECTED] CML Group Web Site http://groups.yahoo.com/group/CML Yahoo! Groups Links <*> To visit your group on the web, go to: http://groups.yahoo.com/group/CML/ <*> To unsubscribe from this group, send an email to: [EMAIL PROTECTED] <*> Your use of Yahoo! Groups is subject to: http://docs.yahoo.com/info/terms/
