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Myeloid cells (granulocytes and monocytes) are derived from multipotent
hematopoietic stem cells. Gene transcription plays a critical role in
hematopoietic differentiation. However, there is no single transcription factor
that is expressed exclusively by myeloid cells and that, alone, acts as a
"master" regulator of myeloid fate choice. Rather, myeloid gene _expression_ is
controlled by the combinatorial effects of several key transcription factors.
Hematopoiesis has traditionally been viewed as linear and hierarchical, but
there is increasing evidence of plasticity during blood cell development.
Transcription factors strongly influence cellular lineage during hematopoiesis
and _expression_ of some transcription factors can alter the fate of developing
hematopoietic progenitor cells.
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